Using lipidomics to reveal details of lipid accumulation in developing seeds from oilseed rape ( Brassica napus L.).

Woodfield HK, Cazenave-Gassiot A, Haslam RP, Guschina IA, Wenk MR, Harwood JL.
Biochim. Biophys. Acta – Mol. Cell Biol. Lipids. (2017). doi:10.1016/j.bbalip.2017.12.010.

Sex differences in 20-hydroxyecdysone hormone levels control sexual dimorphism in Bicyclus anynana wing patterns.

Bhardwaj S, Prudic KL, Bear A, Gupta MD, Wasik BR, Tong X, Cheong WF, Wenk MR, Monteiro A.
Mol Biol Evol. 2017 Nov 20. doi: 10.1093/molbev/msx301.

Deciphering lipid structures based on platform-independent decision rules.

Hartler J, Triebl A, Ziegl A, Trötzmüller M, Rechberger GN, Zeleznik OA, Zierler KA, Torta F, Cazenave-Gassiot A, Wenk MR, Fauland A, Wheelock CE, Armando AM, Quehenberger O, Zhang Q Wakelam MJO, Hämmerle G, Spener F, Köfeler HC, Thallinger GG.
Nat Methods. 2017 Oct 23. doi: 10.1038/nmeth.4470.

Mfsd2b is essential for the sphingosine-1-phosphate export in erythrocytes and platelets.

Vu TM, Ishizu AN, Foo JC, Toh XR, Zhang F, Whee DM, Torta F, Cazenave-Gassiot A, Matsumura T, Kim S, Toh SES, Suda T, Silver DL, Wenk MR, Nguyen LN.
Nature. 2017 Oct 18. doi: 10.1038/nature24053.

Curcumin Ameliorates Neuroinflammation, Neurodegeneration, and Memory Deficits in p25 Transgenic Mouse Model that Bears Hallmarks of Alzheimer’s Disease.

Sundaram JR, Poore CP, Sulaimee NHB, Pareek T, Cheong WF, Wenk MR, Pant HC, Frautschy SA, Low CM, Kesavapany S.
J Alzheimers Dis. 2017 Oct 12. doi: 10.3233/JAD-170093.

Harmonizing Lipidomics: NIST Interlaboratory Comparison Exercise for Lipidomics using Standard Reference Material 1950 Metabolites in Frozen Human Plasma.

Bowden JA, Heckert A, Ulmer CZ, Jones CM, Koelmel JP, Abdullah L, Ahonen L, Alnouti Y, Armando A, Asara JM, Bamba T, Barr JR, Bergquist J, Borchers CH, Brandsma J, Breitkopf SB, Cajka T, Cazenave-Gassiot A, Checa A, Cinel MA, Colas RA, Cremers S, Dennis EA, Evans JE, Fauland A, Fiehn O, Gardner MS, Garrett TJ, Gotlinger KH, Han J, Huang Y, Neo AH, Hyotylainen T, Izumi Y, Jiang H, Jiang H, Jiang J, Kachman M, Kiyonami R, Klavins K, Klose C, Kofeler HC, Kolmert J, Koal T, Koster G, Kuklenyik Z, Kurland IJ, Leadley M, Lin K, Maddipati KR, McDougall D, Meikle PJ, Mellett NA, Monnin C, Moseley MA, Nandakumar R, Oresic M, Patterson RE, Peake D, Pierce JS, Post M, Postle AD, Pugh R, Qui Y, Quehenberger O, Ramrup P, Rees J, Rembiesa B, Reynaud D, Roth MR, Sales S, Schuhmann K, Schwartzman ML, Serhan CN, Shevchenko A, Somerville SE, John-Williams LS, Surma MA, Takeda H, Thakare R, Thompson JW, Torta F, Triebl A, Trötzmüller M, Ubhayasekera SJK, Vuckovic D, Weir JM, Welti R, Wenk MR, Wheelock CE, Yao L, Yuan M, Zhao XH, Zhou S.
J Lipid Res. 2017 Oct 6. pii: jlr.M079012. doi: 10.1194/jlr.M079012.

Establishing multiple omics baselines for three Southeast Asian populations in the Singapore Integrative Omics Study.

Saw WY, Tantoso E, Begum H, Zhou L, Zou R, He C, Chan SL, Tan LW, Wong LP, Xu W, Moong DKN, Lim Y, Li B, Pillai NE, Peterson TA, Bielawny T, Meikle PJ, Mundra PA, Lim WY, Luo M, Chia KS, Ong RT, Brunham LR, Khor CC, Too HP, Soong R, Wenk MR, Little P, Teo YY.
Nat Commun. 2017 Sep 21;8(1):653. doi: 10.1038/s41467-017-00413-x.

ABCA8 Regulates Cholesterol Efflux and High-Density Lipoprotein Cholesterol Levels.

Trigueros-Motos L, van Capelleveen JC, Torta F, Castaño D, Zhang LH, Chai C, Kang M, Dimova LG, Schimmel AWM, Tietjen I, Radomski C, Tan LJ, Hwee TC, Narayanaswamy P, Wu D, Dorninger F, Yakala GK, Barhdadi A, Angeli V, Dubé MP, Berger J, Dallinga-Thie GM, Tietge UJF, Wenk MR, Hayden MR, Hovingh GK, Singaraja RR.
Arterioscler Thromb Vasc Biol. 2017 Sep 7. pii: ATVBAHA.117.309574. doi: 10.1161/ATVBAHA.117.309574.

Global Mapping of Protein-Lipid Interactions by Using Modified Choline-Containing Phospholipids Metabolically Synthesized in Live Cells.

Wang D, Du S, Cazenave-Gassiot A, Ge J, Lee JS, Wenk MR, Yao SQ.
Angew Chem Int Ed Engl. 2017 Apr 21. doi: 10.1002/anie.201702509.

Comprehensive analysis of phospholipids and glycolipids in the opportunistic pathogen Enterococcus faecalis.

Rashid R, Cazenave-Gassiot A, Gao IH, Nair ZJ, Kumar JK, Gao L, Kline KA, Wenk MR.
PLoS One. 2017 Apr 19;12(4):e0175886. doi: 10.1371/journal.pone.0175886. eCollection 2017.

Hypoxia enhances antibody-dependent dengue virus infection.

Gan ES, Cheong WF, Chan KR, Ong EZ, Chai X, Tan HC, Ghosh S, Wenk MR, Ooi EE.
EMBO J. 2017 Mar 20. pii: e201695642. doi: 10.15252/embj.201695642.

Lipid transport by TMEM24 at ER-plasma membrane contacts regulates pulsatile insulin secretion.

Lees JA, Messa M, Sun EW, Wheeler H, Torta F, Wenk MR, De Camilli P, Reinisch KM.

Science. 2017 Feb 17;355(6326). pii: eaah6171. doi: 10.1126/science.aah6171.

A mutation of EPT1 (SELENOI) underlies a new disorder of Kennedy pathway phospholipid biosynthesis.

Ahmed MY, Al-Khayat A, Al-Murshedi F, Al-Futaisi A, Chioza BA, Pedro Fernandez-Murray J, Self JE, Salter CG, Harlalka GV, Rawlins LE, Al-Zuhaibi S, Al-Azri F, Al-Rashdi F, Cazenave-Gassiot A, Wenk MR, Al-Salmi F, Patton MA, Silver DL, Baple EL, McMaster CR, Crosby AH.

Brain. 2017 Jan 3;140(3):547-554.


Characterization of a dynamic metabolon producing the defense compound dhurrin in sorghum.

Laursen T, Borch J, Knudsen C, Bavishi K, Torta F, Martens HJ, Silvestro D, Hatzakis NS, Wenk MR, Dafforn TR, Olsen CE, Motawia MS, Hamberger B, Møller BL, Bassard JE.

Science. 2016 Nov 18;354(6314):890-893.

Role of prefrontal cortical calcium-independent phospholipase A2 in antinociceptive effect of the norepinephrine reuptake inhibitor antidepresssant maprotiline.

Chew WS, Shalini SM, Torta F, Wenk MR, Stohler C, Yeo JF, Herr DR, Ong WY.

Neuroscience. 2017 Jan 6;340:91-100.

Activity-Based Lipid Esterase Profiling of M. bovis BCG at Different Metabolic States Using Tetrahydrolipstatin (THL) as Bait.

Ravindran MS, Wenk MR.

Methods Mol Biol. 2017;1491:75-85.

Defining key roles for auxiliary proteins in an ABC transporter that maintains bacterial outer membrane lipid asymmetry.

Thong S, Ercan B, Torta F, Fong ZY, Wong HY, Wenk MR, Chng SS.

Elife. 2016 Aug 16;5.

Lipid-Based Therapy for Ocular Surface Inflammation and Disease.

Lim A, Wenk MR, Tong L.

Trends Mol Med. 2016 Jul;22(7):629.

Aberrant expression of the S1P regulating enzymes, SPHK1 and SGPL1, contributes to a migratory phenotype in OSCC mediated through S1PR2.

Patmanathan SN, Johnson SP, Lai SL, Panja Bernam S, Lopes V, Wei W, Ibrahim MH, Torta F, Narayanaswamy P, Wenk MR, Herr DR, Murray PG, Yap LF, Paterson IC.

Sci Rep. 2016 May 10;6:25650.

Mfsd2a Is a Transporter for the Essential ω-3 Fatty Acid Docosahexaenoic Acid (DHA) in Eye and Is Important for Photoreceptor Cell Development.

Wong BH, Chan JP, Cazenave-Gassiot A, Poh RW, Foo JC, Galam DL, Ghosh S, Nguyen LN, Barathi VA, Yeo SW, Luu CD, Wenk MR, Silver DL.

J Biol Chem. 2016 May 13;291(20):10501-14.

Sphingosine kinase inhibition ameliorates chronic hypoperfusion-induced white matter lesions.

Yang Y, Torta F, Arai K, Wenk MR, Herr DR, Wong PT, Lai MK.

Neurochem Int. 2016 Mar;94:90-7.

Plasma Phospholipid and Sphingolipid Alterations in Presenilin1 Mutation Carriers: A Pilot Study.

Chatterjee P, Lim WL, Shui G, Gupta VB, James I, Fagan AM, Xiong C, Sohrabi HR, Taddei K, Brown BM, Benzinger T, Masters C, Snowden SG, Wenk MR, Bateman RJ, Morris JC, Martins RN.

J Alzheimers Dis. 2016;50(3):887-94.

Discovering and validating between-subject variations in plasma lipids in healthy subjects.

Begum H, Li B, Shui G, Cazenave-Gassiot A, Soong R, Ong RT, Little P, Teo YY, Wenk MR.

Sci Rep. 2016 Jan 8;6:19139.


Ceramides And Stress Signalling Intersect With Autophagic Defects In Neurodegenerative Drosophila blue cheese (bchs) Mutants.

Hebbar S, Sahoo I, Matysik A, Argudo Garcia I, Osborne KA, Papan C, Torta F, Narayanaswamy P, Fun XH, Wenk MR, Shevchenko A, Schwudke D, Kraut R.

Sci Rep. 2015 Dec 7;5:15926.

Lipid-Based Therapy for Ocular Surface Inflammation and Disease.

Lim A, Wenk MR, Tong L.

Trends Mol Med. 2015 Dec;21(12):736-48.

Differential Expression of Ecdysone Receptor Leads to Variation in Phenotypic Plasticity across Serial Homologs.

Monteiro A, Tong X, Bear A, Liew SF, Bhardwaj S, Wasik BR, Dinwiddie A, Bastianelli C, Cheong WF, Wenk MR, Cao H, Prudic KL.

PLoS Genet. 2015 Sep 25;11(9):e1005529.

Arabidopsis AtPLC2 Is a Primary Phosphoinositide-Specific Phospholipase C in Phosphoinositide Metabolism and the Endoplasmic Reticulum Stress Response.

Kanehara K, Yu CY, Cho Y, Cheong WF, Torta F, Shui G, Wenk MR, Nakamura Y.

PLoS Genet. 2015 Sep 24;11(9):e1005511.

The fusogenic lipid phosphatidic acid promotes the biogenesis of mitochondrial outer membrane protein Ugo1.

Vögtle FN, Keller M, Taskin AA, Horvath SE, Guan XL, Prinz C, Opalińska M, Zorzin C, van der Laan M, Wenk MR, Schubert R, Wiedemann N, Holzer M, Meisinger C.

J Cell Biol. 2015 Sep 14;210(6):951-60.

INTRACELLULAR TRANSPORT. PI4P/phosphatidylserine countertransport at ORP5- and ORP8-mediated ER-plasma membrane contacts.

Chung J, Torta F, Masai K, Lucast L, Czapla H, Tanner LB, Narayanaswamy P, Wenk MR, Nakatsu F, De Camilli P.

Science. 2015 Jul 24;349(6246):428-32.

Changes in Plasma Lipids during Exposure to Total Sleep Deprivation.

Chua EC, Shui G, Cazenave-Gassiot A, Wenk MR, Gooley JJ.

Sleep. 2015 Nov 1;38(11):1683-91.

Phosphatidic acid is a major phospholipid class in reproductive organs of Arabidopsis thaliana.

Yunus IS, Cazenave-Gassiot A, Liu YC, Lin YC, Wenk MR, Nakamura Y.

Plant Signal Behav. 2015;10(8):e1049790.

Co-option of Membrane Wounding Enables Virus Penetration into Cells.

Luisoni S, Suomalainen M, Boucke K, Tanner LB, Wenk MR, Guan XL, Grzybek M, Coskun Ü, Greber UF.

Cell Host Microbe 2015 Jul 8;18(1):75-85.

The Lipid-Modifying Enzyme SMPDL3B Negatively Regulates Innate Immunity.

Heinz LX, Baumann CL, Köberlin MS, Snijder B, Gawish R, Shui G, Sharif O, Aspalter IM, Müller AC, Kandasamy RK, Breitwieser FP, Pichlmair A, Bruckner M, Rebsamen M, Blüml S, Karonitsch T, Fauster A, Colinge J, Bennett KL, Knapp S, Wenk MR, Superti-Furga G.

Cell Rep. 2015 Jun 30;11(12):1919-28.

Inactivating mutations in MFSD2A, required for omega-3 fatty acid transport in brain, cause a lethal microcephaly syndrome.

Guemez-Gamboa A, Nguyen LN, Yang H, Zaki MS, Kara M, Ben-Omran T, Akizu N, Rosti RO, Rosti B, Scott E, Schroth J, Copeland B, Vaux KK, Cazenave-Gassiot A, Quek DQ, Wong BH, Tan BC, Wenk MR, Gunel M, Gabriel S, Chi NC, Silver DL, Gleeson JG.

Nat Genet. 2015 Jul;47(7):809-13.

A partially inactivating mutation in the sodium-dependent lysophosphatidylcholine transporter MFSD2A causes a non-lethal microcephaly syndrome.

Alakbarzade V, Hameed A, Quek DQ, Chioza BA, Baple EL, Cazenave-Gassiot A, Nguyen LN, Wenk MR, Ahmad AQ, Sreekantan-Nair A, Weedon MN, Rich P, Patton MA, Warner TT, Silver DL, Crosby AH.

Nat Genet. 2015 Jul;47(7):814-7.

The diagnostic targeting of a carbohydrate virulence factor from M.Tuberculosis.

Chan CE, Götze S, Seah GT, Seeberger PH, Tukvadze N, Wenk MR, Hanson BJ, MacAry PA.

Sci Rep. 2015 May 15;5:10281.


Rhinovirus uses a phosphatidylinositol 4-phosphate/cholesterol counter-current for the formation of replication compartments at the ER-Golgi interface.

Roulin PS, Lötzerich M, Torta F, Tanner LB, van Kuppeveld FJ, Wenk MR, Greber UF.

Cell Host Microbe. 2014 Nov 12;16(5):677-90.

Lipidomics and genomics of Mycobacterium tuberculosis reveal lineage-specific trends in mycolic acid biosynthesis.

Portevin D, Sukumar S, Coscolla M, Shui G, Li B, Guan XL, Bendt AK, Young D, Gagneux S, Wenk MR.

Microbiologyopen. 2014 Dec;3(6):823-35.

A semi-automated methodology for finding lipid-related GO terms.

Fan M, Low HS, Wenk MR, Wong L.

Database (Oxford). 2014 Sep 10;2014. pii: bau089.

Longitudinal changes in tear fluid lipidome brought about by eyelid-warming treatment in a cohort of meibomian gland dysfunction.

Lam SM, Tong L, Duan X, Acharya UR, Tan JH, Petznick A, Wenk MR, Shui G.

J Lipid Res. 2014 Sep;55(9):1959-69.

Comprehensive analysis of lipid composition in crude palm oil using multiple lipidomic approaches.

Cheong WF, Wenk MR, Shui G.

J Genet Genomics. 2014 May 20;41(5):293-304.

Lipidomics identifies a requirement for peroxisomal function during influenza virus replication.

Tanner LB, Chng C, Guan XL, Lei Z, Rozen SG, Wenk MR.

J Lipid Res. 2014 Jul;55(7):1357-65.

Structure of a lipid-bound extended synaptotagmin indicates a role in lipid transfer.

Schauder CM, Wu X, Saheki Y, Narayanaswamy P, Torta F, Wenk MR, De Camilli P, Reinisch KM.

Nature. 2014 Jun 26;510(7506):552-5.

Insights into the genetic structure and diversity of 38 South Asian Indians from deep whole-genome sequencing.

Wong LP, Lai JK, Saw WY, Ong RT, Cheng AY, Pillai NE, Liu X, Xu W, Chen P, Foo JN, Tan LW, Koo SH, Soong R, Wenk MR, Lim WY, Khor CC, Little P, Chia KS, Teo YY.

PLoS Genet. 2014 May 15;10(5):e1004377.

Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid.

Nguyen LN, Ma D, Shui G, Wong P, Cazenave-Gassiot A, Zhang X, Wenk MR, Goh EL, Silver DL.

Nature. 2014 May 22;509(7501):503-6.

Brain lipidomes of subcortical ischemic vascular dementia and mixed dementia.

Lam SM, Wang Y, Duan X, Wenk MR, Kalaria RN, Chen CP, Lai MK, Shui G.

Neurobiol Aging. 2014 Oct;35(10):2369-81.

Transcriptomic and lipidomic profiles of glycerolipids during Arabidopsis flower development.

Nakamura Y, Teo NZ, Shui G, Chua CH, Cheong WF, Parameswaran S, Koizumi R, Ohta H, Wenk MR, Ito T.

New Phytol. 2014 Jul;203(1):310-22. 24684726

Evaluation of dietary effects on hepatic lipids in high fat and placebo diet fed rats by in vivo MRS and LC-MS techniques.

Yaligar J, Gopalan V, Kiat OW, Sugii S, Shui G, Lam BD, Henry CJ, Wenk MR, Tai ES, Velan SS.

PLoS One. 2014 Mar 17;9(3):e91436.

The mitochondria-targeted antioxidant MitoQ extends lifespan and improves healthspan of a transgenic Caenorhabditis elegans model of Alzheimer disease.

Ng LF, Gruber J, Cheah IK, Goo CK, Cheong WF, Shui G, Sit KP, Wenk MR, Halliwell B.

Free Radic Biol Med. 2014 Jun;71:390-401.

Genome profiling of sterol synthesis shows convergent evolution in parasites and guides chemotherapeutic attack.

Fügi MA, Gunasekera K, Ochsenreiter T, Guan X, Wenk MR, Mäser P.

J Lipid Res. 2014 May;55(5):929-38.

Caveolae regulate the nanoscale organization of the plasma membrane to remotely control Ras signaling.

Ariotti N, Fernández-Rojo MA, Zhou Y, Hill MM, Rodkey TL, Inder KL, Tanner LB, Wenk MR, Hancock JF, Parton RG.

J Cell Biol. 2014 Mar 3;204(5):777-92.

Lipidomic “deep profiling”: an enhanced workflow to reveal new molecular species of signaling lipids.

Narayanaswamy P, Shinde S, Sulc R, Kraut R, Staples G, Thiam CH, Grimm R, Sellergren B, Torta F, Wenk MR.

Anal Chem. 2014 Mar 18;86(6):3043-7.

TPS1 drug design for rice blast disease in magnaporthe oryzae.

Xue Y, Shui G, Wenk MR.

Springerplus. 2014 Jan 10;3:18.

Distribution of secretory phospholipase A2 XIIA in the brain and its role in lipid metabolism and cognition.

Ee SM, Lo YL, Shui G, Wenk MR, Shin EJ, Kim HC, Ong WY.

Mol Neurobiol. 2014 Aug;50(1):60-75.

A computational framework for integration of lipidomics data into metabolic pathways.

Hadadi N, Cher Soh K, Seijo M, Zisaki A, Guan X, Wenk MR, Hatzimanikatis V.

Metab Eng. 2014 May;23:1-8.

Targeting lipid esterases in mycobacteria grown under different physiological conditions using activity-based profiling with tetrahydrolipstatin (THL).

Ravindran MS, Rao SP, Cheng X, Shukla A, Cazenave-Gassiot A, Yao SQ, Wenk MR.

Mol Cell Proteomics. 2014 Feb;13(2):435-48.

LipidGO: database for lipid-related GO terms and applications.

Fan M, Low HS, Zhou H, Wenk MR, Wong L.

Bioinformatics. 2014 Apr 1;30(7):1043-4.

Critical role of SCD1 in autophagy regulation via lipogenesis and lipid rafts-coupled AKT-FOXO1 signaling pathway.

Tan SH, Shui G, Zhou J, Shi Y, Huang J, Xia D, Wenk MR, Shen HM.

Autophagy. 2014 Feb;10(2):226-42.

Lipidomic analysis of human tear fluid reveals structure-specific lipid alterations in dry eye syndrome.

Lam SM, Tong L, Reux B, Duan X, Petznick A, Yong SS, Khee CB, Lear MJ, Wenk MR, Shui G.

J Lipid Res. 2014 Feb;55(2):299-306.

Extensive characterization of human tear fluid collected using different techniques unravels the presence of novel lipid amphiphiles.

Lam SM, Tong L, Duan X, Petznick A, Wenk MR, Shui G.

J Lipid Res. 2014 Feb;55(2):289-98.