Publications

2017

 

Global Mapping of Protein-Lipid Interactions by Using Modified Choline-Containing Phospholipids Metabolically Synthesized in Live Cells.

Wang D, Du S, Cazenave-Gassiot A, Ge J, Lee JS, Wenk MR, Yao SQ.
Angew Chem Int Ed Engl. 2017 Apr 21. doi: 10.1002/anie.201702509. [Epub ahead of print]
Pubmed

Comprehensive analysis of phospholipids and glycolipids in the opportunistic pathogen Enterococcus faecalis.

Rashid R, Cazenave-Gassiot A, Gao IH, Nair ZJ, Kumar JK, Gao L, Kline KA, Wenk MR.
PLoS One. 2017 Apr 19;12(4):e0175886. doi: 10.1371/journal.pone.0175886. eCollection 2017.
Pubmed

Hypoxia enhances antibody-dependent dengue virus infection.

Gan ES, Cheong WF, Chan KR, Ong EZ, Chai X, Tan HC, Ghosh S, Wenk MR, Ooi EE.
EMBO J. 2017 Mar 20. pii: e201695642. doi: 10.15252/embj.201695642. [Epub ahead of print].
Pubmed

Lipid transport by TMEM24 at ER-plasma membrane contacts regulates pulsatile insulin secretion.

Lees JA, Messa M, Sun EW, Wheeler H, Torta F, Wenk MR, De Camilli P, Reinisch KM.

Science. 2017 Feb 17;355(6326). pii: eaah6171. doi: 10.1126/science.aah6171.
https://www.ncbi.nlm.nih.gov/pubmed/28209843

A mutation of EPT1 (SELENOI) underlies a new disorder of Kennedy pathway phospholipid biosynthesis.

Ahmed MY, Al-Khayat A, Al-Murshedi F, Al-Futaisi A, Chioza BA, Pedro Fernandez-Murray J, Self JE, Salter CG, Harlalka GV, Rawlins LE, Al-Zuhaibi S, Al-Azri F, Al-Rashdi F, Cazenave-Gassiot A, Wenk MR, Al-Salmi F, Patton MA, Silver DL, Baple EL, McMaster CR, Crosby AH.

Brain. 2017 Jan 3;140(3):547-554.
https://www.ncbi.nlm.nih.gov/pubmed/28052917

2016

Characterization of a dynamic metabolon producing the defense compound dhurrin in sorghum.

Laursen T, Borch J, Knudsen C, Bavishi K, Torta F, Martens HJ, Silvestro D, Hatzakis NS, Wenk MR, Dafforn TR, Olsen CE, Motawia MS, Hamberger B, Møller BL, Bassard JE.

Science. 2016 Nov 18;354(6314):890-893.
https://www.ncbi.nlm.nih.gov/pubmed/27856908

Role of prefrontal cortical calcium-independent phospholipase A2 in antinociceptive effect of the norepinephrine reuptake inhibitor antidepresssant maprotiline.

Chew WS, Shalini SM, Torta F, Wenk MR, Stohler C, Yeo JF, Herr DR, Ong WY.

Neuroscience. 2017 Jan 6;340:91-100.
https://www.ncbi.nlm.nih.gov/pubmed/27789386

Activity-Based Lipid Esterase Profiling of M. bovis BCG at Different Metabolic States Using Tetrahydrolipstatin (THL) as Bait.

Ravindran MS, Wenk MR.

Methods Mol Biol. 2017;1491:75-85.
https://www.ncbi.nlm.nih.gov/pubmed/27778282

Defining key roles for auxiliary proteins in an ABC transporter that maintains bacterial outer membrane lipid asymmetry.

Thong S, Ercan B, Torta F, Fong ZY, Wong HY, Wenk MR, Chng SS.

Elife. 2016 Aug 16;5.
https://www.ncbi.nlm.nih.gov/pubmed/27529189

Lipid-Based Therapy for Ocular Surface Inflammation and Disease.

Lim A, Wenk MR, Tong L.

Trends Mol Med. 2016 Jul;22(7):629.
https://www.ncbi.nlm.nih.gov/pubmed/27282088

Aberrant expression of the S1P regulating enzymes, SPHK1 and SGPL1, contributes to a migratory phenotype in OSCC mediated through S1PR2.

Patmanathan SN, Johnson SP, Lai SL, Panja Bernam S, Lopes V, Wei W, Ibrahim MH, Torta F, Narayanaswamy P, Wenk MR, Herr DR, Murray PG, Yap LF, Paterson IC.

Sci Rep. 2016 May 10;6:25650.
https://www.ncbi.nlm.nih.gov/pubmed/27160553

Mfsd2a Is a Transporter for the Essential ω-3 Fatty Acid Docosahexaenoic Acid (DHA) in Eye and Is Important for Photoreceptor Cell Development.

Wong BH, Chan JP, Cazenave-Gassiot A, Poh RW, Foo JC, Galam DL, Ghosh S, Nguyen LN, Barathi VA, Yeo SW, Luu CD, Wenk MR, Silver DL.

J Biol Chem. 2016 May 13;291(20):10501-14.
https://www.ncbi.nlm.nih.gov/pubmed/27008858

Sphingosine kinase inhibition ameliorates chronic hypoperfusion-induced white matter lesions.

Yang Y, Torta F, Arai K, Wenk MR, Herr DR, Wong PT, Lai MK.

Neurochem Int. 2016 Mar;94:90-7.
https://www.ncbi.nlm.nih.gov/pubmed/26921668

Plasma Phospholipid and Sphingolipid Alterations in Presenilin1 Mutation Carriers: A Pilot Study.

Chatterjee P, Lim WL, Shui G, Gupta VB, James I, Fagan AM, Xiong C, Sohrabi HR, Taddei K, Brown BM, Benzinger T, Masters C, Snowden SG, Wenk MR, Bateman RJ, Morris JC, Martins RN.

J Alzheimers Dis. 2016;50(3):887-94.
https://www.ncbi.nlm.nih.gov/pubmed/26836186

Discovering and validating between-subject variations in plasma lipids in healthy subjects.

Begum H, Li B, Shui G, Cazenave-Gassiot A, Soong R, Ong RT, Little P, Teo YY, Wenk MR.

Sci Rep. 2016 Jan 8;6:19139.
https://www.ncbi.nlm.nih.gov/pubmed/26743939

2015

Ceramides And Stress Signalling Intersect With Autophagic Defects In Neurodegenerative Drosophila blue cheese (bchs) Mutants.

Hebbar S, Sahoo I, Matysik A, Argudo Garcia I, Osborne KA, Papan C, Torta F, Narayanaswamy P, Fun XH, Wenk MR, Shevchenko A, Schwudke D, Kraut R.

Sci Rep. 2015 Dec 7;5:15926.
http://www.ncbi.nlm.nih.gov/pubmed/26639035

Lipid-Based Therapy for Ocular Surface Inflammation and Disease.

Lim A, Wenk MR, Tong L.

Trends Mol Med. 2015 Dec;21(12):736-48.
http://www.ncbi.nlm.nih.gov/pubmed/26596867

Differential Expression of Ecdysone Receptor Leads to Variation in Phenotypic Plasticity across Serial Homologs.

Monteiro A, Tong X, Bear A, Liew SF, Bhardwaj S, Wasik BR, Dinwiddie A, Bastianelli C, Cheong WF, Wenk MR, Cao H, Prudic KL.

PLoS Genet. 2015 Sep 25;11(9):e1005529.
http://www.ncbi.nlm.nih.gov/pubmed/26405828

Arabidopsis AtPLC2 Is a Primary Phosphoinositide-Specific Phospholipase C in Phosphoinositide Metabolism and the Endoplasmic Reticulum Stress Response.

Kanehara K, Yu CY, Cho Y, Cheong WF, Torta F, Shui G, Wenk MR, Nakamura Y.

PLoS Genet. 2015 Sep 24;11(9):e1005511.
http://www.ncbi.nlm.nih.gov/pubmed/26401841

The fusogenic lipid phosphatidic acid promotes the biogenesis of mitochondrial outer membrane protein Ugo1.

Vögtle FN, Keller M, Taskin AA, Horvath SE, Guan XL, Prinz C, Opalińska M, Zorzin C, van der Laan M, Wenk MR, Schubert R, Wiedemann N, Holzer M, Meisinger C.

J Cell Biol. 2015 Sep 14;210(6):951-60.
http://www.ncbi.nlm.nih.gov/pubmed/26347140

INTRACELLULAR TRANSPORT. PI4P/phosphatidylserine countertransport at ORP5- and ORP8-mediated ER-plasma membrane contacts.

Chung J, Torta F, Masai K, Lucast L, Czapla H, Tanner LB, Narayanaswamy P, Wenk MR, Nakatsu F, De Camilli P.

Science. 2015 Jul 24;349(6246):428-32.
http://www.ncbi.nlm.nih.gov/pubmed/26206935

Changes in Plasma Lipids during Exposure to Total Sleep Deprivation.

Chua EC, Shui G, Cazenave-Gassiot A, Wenk MR, Gooley JJ.

Sleep. 2015 Nov 1;38(11):1683-91.
http://www.ncbi.nlm.nih.gov/pubmed/26194579

Phosphatidic acid is a major phospholipid class in reproductive organs of Arabidopsis thaliana.

Yunus IS, Cazenave-Gassiot A, Liu YC, Lin YC, Wenk MR, Nakamura Y.

Plant Signal Behav. 2015;10(8):e1049790.
http://www.ncbi.nlm.nih.gov/pubmed/26179579

Co-option of Membrane Wounding Enables Virus Penetration into Cells.

Luisoni S, Suomalainen M, Boucke K, Tanner LB, Wenk MR, Guan XL, Grzybek M, Coskun Ü, Greber UF.

Cell Host Microbe 2015 Jul 8;18(1):75-85.
http://www.ncbi.nlm.nih.gov/pubmed/26159720

The Lipid-Modifying Enzyme SMPDL3B Negatively Regulates Innate Immunity.

Heinz LX, Baumann CL, Köberlin MS, Snijder B, Gawish R, Shui G, Sharif O, Aspalter IM, Müller AC, Kandasamy RK, Breitwieser FP, Pichlmair A, Bruckner M, Rebsamen M, Blüml S, Karonitsch T, Fauster A, Colinge J, Bennett KL, Knapp S, Wenk MR, Superti-Furga G.

Cell Rep. 2015 Jun 30;11(12):1919-28.
http://www.ncbi.nlm.nih.gov/pubmed/26095358

Inactivating mutations in MFSD2A, required for omega-3 fatty acid transport in brain, cause a lethal microcephaly syndrome.

Guemez-Gamboa A, Nguyen LN, Yang H, Zaki MS, Kara M, Ben-Omran T, Akizu N, Rosti RO, Rosti B, Scott E, Schroth J, Copeland B, Vaux KK, Cazenave-Gassiot A, Quek DQ, Wong BH, Tan BC, Wenk MR, Gunel M, Gabriel S, Chi NC, Silver DL, Gleeson JG.

Nat Genet. 2015 Jul;47(7):809-13.
http://www.ncbi.nlm.nih.gov/pubmed/26005868

A partially inactivating mutation in the sodium-dependent lysophosphatidylcholine transporter MFSD2A causes a non-lethal microcephaly syndrome.

Alakbarzade V, Hameed A, Quek DQ, Chioza BA, Baple EL, Cazenave-Gassiot A, Nguyen LN, Wenk MR, Ahmad AQ, Sreekantan-Nair A, Weedon MN, Rich P, Patton MA, Warner TT, Silver DL, Crosby AH.

Nat Genet. 2015 Jul;47(7):814-7.
http://www.ncbi.nlm.nih.gov/pubmed/26005865

The diagnostic targeting of a carbohydrate virulence factor from M.Tuberculosis.

Chan CE, Götze S, Seah GT, Seeberger PH, Tukvadze N, Wenk MR, Hanson BJ, MacAry PA.

Sci Rep. 2015 May 15;5:10281.
http://www.ncbi.nlm.nih.gov/pubmed/25975873

2014

Rhinovirus uses a phosphatidylinositol 4-phosphate/cholesterol counter-current for the formation of replication compartments at the ER-Golgi interface.

Roulin PS, Lötzerich M, Torta F, Tanner LB, van Kuppeveld FJ, Wenk MR, Greber UF.

Cell Host Microbe. 2014 Nov 12;16(5):677-90.
http://www.ncbi.nlm.nih.gov/pubmed/25525797

Lipidomics and genomics of Mycobacterium tuberculosis reveal lineage-specific trends in mycolic acid biosynthesis.

Portevin D, Sukumar S, Coscolla M, Shui G, Li B, Guan XL, Bendt AK, Young D, Gagneux S, Wenk MR.

Microbiologyopen. 2014 Dec;3(6):823-35.
http://www.ncbi.nlm.nih.gov/pubmed/25238051

A semi-automated methodology for finding lipid-related GO terms.

Fan M, Low HS, Wenk MR, Wong L.

Database (Oxford). 2014 Sep 10;2014. pii: bau089.
http://www.ncbi.nlm.nih.gov/pubmed/25209026

Longitudinal changes in tear fluid lipidome brought about by eyelid-warming treatment in a cohort of meibomian gland dysfunction.

Lam SM, Tong L, Duan X, Acharya UR, Tan JH, Petznick A, Wenk MR, Shui G.

J Lipid Res. 2014 Sep;55(9):1959-69.
http://www.ncbi.nlm.nih.gov/pubmed/24994912

Comprehensive analysis of lipid composition in crude palm oil using multiple lipidomic approaches.

Cheong WF, Wenk MR, Shui G.

J Genet Genomics. 2014 May 20;41(5):293-304.
http://www.ncbi.nlm.nih.gov/pubmed/24894356

Lipidomics identifies a requirement for peroxisomal function during influenza virus replication.

Tanner LB, Chng C, Guan XL, Lei Z, Rozen SG, Wenk MR.

J Lipid Res. 2014 Jul;55(7):1357-65.
http://www.ncbi.nlm.nih.gov/pubmed/24868094

Structure of a lipid-bound extended synaptotagmin indicates a role in lipid transfer.

Schauder CM, Wu X, Saheki Y, Narayanaswamy P, Torta F, Wenk MR, De Camilli P, Reinisch KM.

Nature. 2014 Jun 26;510(7506):552-5.
http://www.ncbi.nlm.nih.gov/pubmed/24847877

Insights into the genetic structure and diversity of 38 South Asian Indians from deep whole-genome sequencing.

Wong LP, Lai JK, Saw WY, Ong RT, Cheng AY, Pillai NE, Liu X, Xu W, Chen P, Foo JN, Tan LW, Koo SH, Soong R, Wenk MR, Lim WY, Khor CC, Little P, Chia KS, Teo YY.

PLoS Genet. 2014 May 15;10(5):e1004377.
http://www.ncbi.nlm.nih.gov/pubmed/24832686

Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid.

Nguyen LN, Ma D, Shui G, Wong P, Cazenave-Gassiot A, Zhang X, Wenk MR, Goh EL, Silver DL.

Nature. 2014 May 22;509(7501):503-6.
http://www.ncbi.nlm.nih.gov/pubmed/24828044

Brain lipidomes of subcortical ischemic vascular dementia and mixed dementia.

Lam SM, Wang Y, Duan X, Wenk MR, Kalaria RN, Chen CP, Lai MK, Shui G.

Neurobiol Aging. 2014 Oct;35(10):2369-81.
http://www.ncbi.nlm.nih.gov/pubmed/24684787

Transcriptomic and lipidomic profiles of glycerolipids during Arabidopsis flower development.

Nakamura Y, Teo NZ, Shui G, Chua CH, Cheong WF, Parameswaran S, Koizumi R, Ohta H, Wenk MR, Ito T.

New Phytol. 2014 Jul;203(1):310-22. 24684726
https://www.ncbi.nlm.nih.gov/pubmed/24684726

Evaluation of dietary effects on hepatic lipids in high fat and placebo diet fed rats by in vivo MRS and LC-MS techniques.

Yaligar J, Gopalan V, Kiat OW, Sugii S, Shui G, Lam BD, Henry CJ, Wenk MR, Tai ES, Velan SS.

PLoS One. 2014 Mar 17;9(3):e91436.
http://www.ncbi.nlm.nih.gov/pubmed/24638096

The mitochondria-targeted antioxidant MitoQ extends lifespan and improves healthspan of a transgenic Caenorhabditis elegans model of Alzheimer disease.

Ng LF, Gruber J, Cheah IK, Goo CK, Cheong WF, Shui G, Sit KP, Wenk MR, Halliwell B.

Free Radic Biol Med. 2014 Jun;71:390-401.
http://www.ncbi.nlm.nih.gov/pubmed/24637264

Genome profiling of sterol synthesis shows convergent evolution in parasites and guides chemotherapeutic attack.

Fügi MA, Gunasekera K, Ochsenreiter T, Guan X, Wenk MR, Mäser P.

J Lipid Res. 2014 May;55(5):929-38.
http://www.ncbi.nlm.nih.gov/pubmed/24627128

Caveolae regulate the nanoscale organization of the plasma membrane to remotely control Ras signaling.

Ariotti N, Fernández-Rojo MA, Zhou Y, Hill MM, Rodkey TL, Inder KL, Tanner LB, Wenk MR, Hancock JF, Parton RG.

J Cell Biol. 2014 Mar 3;204(5):777-92.
http://www.ncbi.nlm.nih.gov/pubmed/24567358

Lipidomic “deep profiling”: an enhanced workflow to reveal new molecular species of signaling lipids.

Narayanaswamy P, Shinde S, Sulc R, Kraut R, Staples G, Thiam CH, Grimm R, Sellergren B, Torta F, Wenk MR.

Anal Chem. 2014 Mar 18;86(6):3043-7.
http://www.ncbi.nlm.nih.gov/pubmed/24533588

TPS1 drug design for rice blast disease in magnaporthe oryzae.

Xue Y, Shui G, Wenk MR.

Springerplus. 2014 Jan 10;3:18.
http://www.ncbi.nlm.nih.gov/pubmed/24478940

Distribution of secretory phospholipase A2 XIIA in the brain and its role in lipid metabolism and cognition.

Ee SM, Lo YL, Shui G, Wenk MR, Shin EJ, Kim HC, Ong WY.

Mol Neurobiol. 2014 Aug;50(1):60-75.
http://www.ncbi.nlm.nih.gov/pubmed/24464264

A computational framework for integration of lipidomics data into metabolic pathways.

Hadadi N, Cher Soh K, Seijo M, Zisaki A, Guan X, Wenk MR, Hatzimanikatis V.

Metab Eng. 2014 May;23:1-8.
http://www.ncbi.nlm.nih.gov/pubmed/24395008

Targeting lipid esterases in mycobacteria grown under different physiological conditions using activity-based profiling with tetrahydrolipstatin (THL).

Ravindran MS, Rao SP, Cheng X, Shukla A, Cazenave-Gassiot A, Yao SQ, Wenk MR.

Mol Cell Proteomics. 2014 Feb;13(2):435-48.
http://www.ncbi.nlm.nih.gov/pubmed/24345785

LipidGO: database for lipid-related GO terms and applications.

Fan M, Low HS, Zhou H, Wenk MR, Wong L.

Bioinformatics. 2014 Apr 1;30(7):1043-4.
http://www.ncbi.nlm.nih.gov/pubmed/24297518

Critical role of SCD1 in autophagy regulation via lipogenesis and lipid rafts-coupled AKT-FOXO1 signaling pathway.

Tan SH, Shui G, Zhou J, Shi Y, Huang J, Xia D, Wenk MR, Shen HM.

Autophagy. 2014 Feb;10(2):226-42.
http://www.ncbi.nlm.nih.gov/pubmed/24296537

Lipidomic analysis of human tear fluid reveals structure-specific lipid alterations in dry eye syndrome.

Lam SM, Tong L, Reux B, Duan X, Petznick A, Yong SS, Khee CB, Lear MJ, Wenk MR, Shui G.

J Lipid Res. 2014 Feb;55(2):299-306.
http://www.ncbi.nlm.nih.gov/pubmed/24287121

Extensive characterization of human tear fluid collected using different techniques unravels the presence of novel lipid amphiphiles.

Lam SM, Tong L, Duan X, Petznick A, Wenk MR, Shui G.

J Lipid Res. 2014 Feb;55(2):289-98.
http://www.ncbi.nlm.nih.gov/pubmed/24287120