Blood-derived lysophospholipid sustains hepatic phospholipids and fat storage necessary for hepatoprotection in overnutrition.

Chin CC, Galam DLA, Gao L, Tan BC, Wong BH, Chua GL, Loke RY, Lim YC, Wenk MR, Lim MS, Leow WQ, Goh GB, Torta F, Silver DL.
J. Clin. Invest. 2023 Sep 1,133(17):e171267 doi: 10.1172/JCI171267.

Myo-inositol alters the effects of glucose, leptin and insulin on placental palmitic acid and oleic acid metabolism.

Watkins OC, Pillai RA, Selvam P, Yong HEJ, Cracknell-Hazra VKB, Sharma N, Cazenave-Gassiot A, Bendt AK, Godfrey KM, Lewis RM, Wenk MR, Chan SY.
J. Physiol. 2023 Aug 21 doi: 10.1113/JP285036.

Decreased DHA-containing phospholipids in the neocortex of dementia with Lewy bodies are associated with soluble Aβ42 , phosphorylated α-synuclein, and synaptopathology.

Chong JR, Chai YL, Xing H, Herr DR, Wenk MR, Francis PT, Ballard C, Aarsland D, Silver DL, Chen CP, Cazenave-Gassiot A, Lai MKP.
Brain Pathol. 2023 Jul 18;e13190. doi: 10.1111/bpa.13190.

Blood-derived lysophospholipid sustains hepatic phospholipids and fat storage necessary for hepatoprotection in overnutrition.

Chin CF, Galam D, Gao L, Tan BC, Wong BH, Chua GL, Y J Loke R, Lim YC, Wenk MR, Lim MS, Leow WQ, Goh GB, Torta F, Silver DL.
J Clin Invest. 2023 Jul 18;e171267. doi: 10.1172/JCI171267.

Mfsd2a-mediated lysolipid transport is important for renal recovery after acute kidney injury.

Loke RYJ, Chin CF, Liang G, Wong BH, Galam DLA, Tan BC, Chua GL, Minegishi S, Morisawa N, Sidorov I, Heijs B, Titze J, Wenk MR, Torta F, Silver DL.
J Lipid Res. 2023 Jul 17;64(8):100416. doi: 10.1016/j.jlr.2023.100416.

Restoration of PITPNA in Type 2 diabetic human islets reverses pancreatic beta-cell dysfunction.

Yeh YT, Sona C, Yan X, Li Y, Pathak A, McDermott MI, Xie Z, Liu L, Arunagiri A, Wang Y, Cazenave-Gassiot A, Ghosh A, von Meyenn F, Kumarasamy S, Najjar SM, Jia S, Wenk MR, Traynor-Kaplan A, Arvan P, Barg S, Bankaitis VA, Poy MN.
Nat Commun. 2023 Jul 17;14(1):4250. doi: 10.1038/s41467-023-39978-1.

Deficiency in the omega-3 lysolipid transporter Mfsd2a leads to aberrant oligodendrocyte lineage development and hypomyelination.

Sengottuvel V, Hota M, Oh J, Galam DL, Wong BH, Wenk MR, Ghosh S, Torta F, Silver DL.
J Clin Invest. 2023 Jun 15;133(12):e164118. doi: 10.1172/JCI164118.

Increasing maternal age associates with lower placental CPT1B mRNA expression and acylcarnitines, particularly in overweight women.

Yong HEJ, Watkins OC, Mah TKL, Cracknell-Hazra VKB, Pillai RA, Selvam P, Islam MO, Sharma N, Cazenave-Gassiot A, Bendt AK, Wenk MR, Godfrey KM, Lewis RM, Chan SY.
Front Physiol. 2023 May 18;14:1166827. doi: 10.3389/fphys.2023.1166827.

An integrated signature of extracellular matrix proteins and a diastolic function imaging parameter predicts post-MI long-term outcomes.

Koh HWL, Pilbrow AP, Tan SH, Zhao Q, Benke PI, Burla B, Torta F, Pickering JW, Troughton R, Pemberton C, Soo WM, Ling LH, Doughty RN, Choi H, Wenk MR, Richards AM, Chan MY.
Front Cardiovasc Med. 2023 Apr 12;10:1123682. doi: 10.3389/fcvm.2023.1123682.

Mfsd2a utilizes a flippase mechanism to mediate omega-3 fatty acid lysolipid transport.

Chua GL, Tan BC, Loke RYJ, He M, Chin CF, Wong BH, Kuk ACY, Ding M, Wenk MR, Guan L, Torta F, Silver DL.
mBio. 2023 Feb 28;14(1):e0307322. doi: 10.1073/pnas.2215290120.

Depleting Cationic Lipids Involved in Antimicrobial Resistance Drives Adaptive Lipid Remodeling in Enterococcus faecalis.

Rashid R, Nair ZJ, Chia DMH, Chong KKL, Cazenave Gassiot A, Morley SA, Allen DK, Chen SL, Chng SS, Wenk MR, Kline KA.
mBio. 2023 Feb 28;14(1):e0307322. doi: 10.1128/mbio.03073-22.

Lysosomal phospholipase A2 contributes to the biosynthesis of the atypical late endosome lipid bis(monoacylglycero)phosphate.

Chen J, Cazenave-Gassiot A, Xu Y, Piroli P, Hwang R Jr, DeFreitas L, Chan RB, Di Paolo G, Nandakumar R, Wenk MR, Marquer C.
Commun Biol. 2023 Feb 23;6(1):210. doi: 10.1038/s42003-023-04573-z.

Plasma lipidomic profiling reveals metabolic adaptations to pregnancy and signatures of cardiometabolic risk: a preconception and longitudinal cohort study.

Chen L, Mir SA, Bendt AK, Chua EWL, Narasimhan K, Tan KM, Loy SL, Tan KH, Shek LP, Chan J, Yap F, Meaney MJ, Chan SY, Chong YS, Gluckman PD, Eriksson JG, Karnani N, Wenk MR.
BMC Med. 2023 Feb 13;21(1):53. doi: 10.1186/s12916-023-02740-x.

Diacylglycerol at the inner nuclear membrane fuels nuclear envelope expansion in closed mitosis.

Foo S, Cazenave-Gassiot A, Wenk MR, Oliferenko S.
J Cell Sci. 2023 Feb 1;136(3):jcs260568. doi: 10.1242/jcs.260568.

Mass Spectrometry Analysis of the Human Brain Sphingolipidome.

Chua XY, Huang R, Herr D, Lai MKP, Wenk MR, Torta F.
Methods Mol Biol. 2023;2561:233-243. doi: 10.1007/978-1-0716-2655-9_12.

Clinical variable-based cluster analysis identifies novel subgroups with a distinct genetic signature, lipidomic pattern and cardio-renal risks in Asian patients with recent-onset type 2 diabetes.


Wang J, Liu JJ, Gurung RL, Liu S, Lee J, M Y, Ang K, Shao YM, Tang JI, Benke PI, Torta F, Wenk MR, Tavintharan S, Tang WE, Sum CF, Lim SC.
Diabetologia. 2022 Dec;65(12):2146-2156. doi: 10.1007/s00125-022-05741-2.

Magnetic field therapy enhances muscle mitochondrial bioenergetics and attenuates systemic ceramide levels following ACL reconstruction: Southeast Asian randomized-controlled pilot trial.

Stephenson MC, Krishna L, Pannir Selvan RM, Tai YK, Kit Wong CJ, Yin JN, Toh SJ, Torta F, Triebl A, Fröhlich J, Beyer C, Li JZ, Tan SS, Wong CK, Chinnasamy D, Pakkiri LS, Lee Drum C, Wenk MR, Totman JJ, Franco-Obregón A.
J Orthop Translat. 2022 Oct 13;35:99-112. doi: 10.1016/ eCollection 2022 Jul.

Spns1 is a lysophospholipid transporter mediating lysosomal phospholipid salvage.

He M, Kuk ACY, Ding M, Chin CF, Galam DLA, Nah JM, Tan BC, Yeo HL, Chua GL, Benke PI, Wenk MR, Ho L, Torta F, Silver DL.
Proc Natl Acad Sci U S A. 2022 Oct 4;119(40):e2210353119. doi: 10.1073/pnas.2210353119.

Myo-Inositol Moderates Glucose-Induced Effects on Human Placental 13C-Arachidonic Acid Metabolism.

Watkins OC, Cracknell-Hazra VKB, Pillai RA, Selvam P, Yong HEJ, Sharma N, Patmanathan SN, Cazenave-Gassiot A, Bendt AK, Godfrey KM, Lewis RM, Wenk MR, Chan SY.
Nutrients. 2022 Sep 26;14(19):3988. doi: 10.3390/nu14193988.

Brain lipidomics: From functional landscape to clinical significance.

Yoon JH, Seo Y, Jo YS, Lee S, Cho E, Cazenave-Gassiot A, Shin YS, Moon MH, An HJ, Wenk MR, Suh PG.
Sci Adv. 2022 Sep 16;8(37):eadc9317. doi: 10.1126/sciadv.adc9317. Epub 2022 Sep 16.

Myo-inositol moderates maternal BMI and glycemia related variations in in-vitro placental 13 C-DHA-metabolism, altering their relationships with birthweight

Watkins OC, Selvam P, Pillai RA, Cracknell-Hazra VKB, Yong HEJ, Sharma N, Cazenave-Gassiot A, Bendt AK, Godfrey KM, Lewis RM, Wenk MR, Chan SY.
Sci Rep. 2022 Sep 1;12(1):14895. doi: 10.1038/s41598-022-18309-2.

Understanding the systemic burden of disease in hidradenitis suppurativa from plasma lipidomic analysis

Choi E, Mir SA, Ji S, Ooi XT, Chua EWL, Yi Wei Y, Wenk MR, Bendt AK, Chandran NS.
J Dermatol Sci. 2022 Aug 15:S0923-1811(22)00196-7. doi: 10.1016/j.jdermsci.2022.08.005. Online ahead of print.

Evaluation of Normalization Approaches for Quantitative Analysis of Bile Acids in Human Feces

Schött HF, Chua EWL, Mir SA, Burla B, Bendt AK, Wenk MR.
Metabolites. 2022 Aug 5;12(8):723. doi: 10.3390/metabo12080723.

Mfsd2b and Spns2 are essential for maintenance of blood vessels during development and in anaphylactic shock

Le TNU, Nguyen TQ, Kalailingam P, Nguyen YTK, Sukumar VK, Tan CKH, Tukijan F, Couty L, Hasan Z, Del Gaudio I, Wenk MR, Cazenave-Gassiot A, Camerer E, Nguyen LN.
Cell Rep. 2022 Aug 16;40(7):111208. doi: 10.1016/j.celrep.2022.111208.

Sex-Dependent Regulation of Placental Oleic Acid and Palmitic Acid Metabolism by Maternal Glycemia and Associations with Birthweight

Watkins OC, Yong HEJ, Mah TKL, Cracknell-Hazra VKB, Pillai RA, Selvam P, Sharma N, Cazenave-Gassiot A, Bendt AK, Godfrey KM, Lewis RM, Wenk MR, Chan SY.
Int J Mol Sci. 2022 Aug 4;23(15):8685. doi: 10.3390/ijms23158685.

Introducing the Lipidomics Minimal Reporting Checklist

McDonald JG, Ejsing CS, Kopczynski D, Holčapek M, Aoki J, Arita M, Arita M, Baker ES, Bertrand-Michel J, Bowden JA, Brügger B, Ellis SR, Fedorova M, Griffiths WJ, Han X, Hartler J, Hoffmann N, Koelmel JP, Köfeler HC, Mitchell TW, O’Donnell VB, Saigusa D, Schwudke D, Shevchenko A, Ulmer CZ, Wenk MR, Witting M, Wolrab D, Xia Y, Ahrends R, Liebisch G, Ekroos K.
Nat Metab. 2022 Aug 8. doi: 10.1038/s42255-022-00628-3. Online ahead of print.

Population-based plasma lipidomics reveals developmental changes in metabolism and signatures of obesity risk: a mother-offspring cohort study

Mir SA, Chen L, Burugupalli S, Burla B, Ji S, Smith AAT, Narasimhan K, Ramasamy A, Tan KM, Huynh K, Giles C, Mei D, Wong G, Yap F, Tan KH, Collier F, Saffery R, Vuillermin P, Bendt AK, Burgner D, Ponsonby AL, Lee YS, Chong YS, Gluckman PD, Eriksson JG, Meikle PJ, Wenk MR, Karnani N.
BMC Med. 2022 Jul 25;20(1):242. doi: 10.1186/s12916-022-02432-y.

Immunolipidomics Reveals a Globoside Network During the Resolution of Pro-Inflammatory Response in Human Macrophages

Muralidharan S, Torta F, Lin MK, Olona A, Bagnati M, Moreno-Moral A, Ko JH, Ji S, Burla B, Wenk MR, Rodrigues HG, Petretto E, Behmoaras J.
Front Immunol. 2022 Jun 30;13:926220. doi: 10.3389/fimmu.2022.926220. eCollection 2022.

Clinical variable-based cluster analysis identifies novel subgroups with a distinct genetic signature, lipidomic pattern and cardio-renal risks in Asian patients with recent-onset type 2 diabetes

Wang J, Liu JJ, Gurung RL, Liu S, Lee J, M Y, Ang K, Shao YM, Tang JI, Benke PI, Torta F, Wenk MR, Tavintharan S, Tang WE, Sum CF, Lim SC.
Diabetologia. 2022 Jun 28. doi: 10.1007/s00125-022-05741-2. Online ahead of print.

Clock: A Lipid-Based Predictor of Biological Age

Unfried M, Ng LF, Cazenave-Gassiot A, Batchu KC, Kennedy BK, Wenk MR, Tolwinski N, Gruber J.
Front Aging. 2022 May 27;3:828239. doi: 10.3389/fragi.2022.828239. eCollection 2022.

Serum Lipidome Signatures of Dogs with Different Endocrinopathies Associated with Hyperlipidemia

Sieber-Ruckstuhl NS, Tham WK, Baumgartner F, Selva JJ, Wenk MR, Burla B, Boretti FS.
Metabolites. 2022 Mar 30;12(4):306. doi: 10.3390/metabo12040306.

Integrative Multi-Omics database (iMOMdb) of Asian Pregnant Women

Pan H, Tan PF, Lim IY, Huan J, Teh AL, Chen L, Gong M, Tin F, Mir SA, Narasimhan K, Chan JKY, Tan KH, Kobor MS, Meikle PJ, Wenk MR, Chong YS, Eriksson JG, Gluckman PD, Karnani N.
Hum Mol Genet. 2022 Apr 21:ddac079. doi: 10.1093/hmg/ddac079. Online ahead of print.

Lipid bilayer composition as a determinant of cancer cell sensitivity to tumoricidal protein-lipid complexes

Ho JCS, Mir SA, Cavalera M, Esmaeili P, Tran TH, Yann ZC, Tran TH, Chaudhuri A, Bendt AK, Wenk MR, Svanborg C.
Biofactors. 2022 Apr 7. doi: 10.1002/biof.1841. Online ahead of print.

Abundant circulating lipids – a new opportunity for NSCLC detection?

Wenk MR, Choi H.
Nat Rev Clin Oncol. 2022 Mar 28. doi: 10.1038/s41571-022-00621-5. Online ahead of print.

Destabilization of β Cell FIT2 by saturated fatty acids alter lipid droplet numbers and contribute to ER stress and diabetes

Zheng X, Ho QWC, Chua M, Stelmashenko O, Yeo XY, Muralidharan S, Torta F, Chew EGY, Lian MM, Foo JN, Jung S, Wong SH, Tan NS, Tong N, Rutter GA, Wenk MR, Silver DL, Berggren PO, Ali Y.
Proc Natl Acad Sci U S A. 2022 Mar 15;119(11):e2113074119. doi: 10.1073/pnas.2113074119. Epub 2022 Mar 7.

The lipid transporter Mfsd2a maintains pulmonary surfactant homeostasis

Wong BH, Mei D, Chua GL, Galam DL, Wenk MR, Torta F, Silver DL.
J Biol Chem. 2022 Feb 9:101709. doi: 10.1016/j.jbc.2022.101709.

Ontogeny of circulating lipid metabolism in pregnancy and early childhood: a longitudinal population study

Burugupalli S, Smith AAT, Oshlensky G, Huynh K, Giles C, Wang T, George A, Paul S, Nguyen A, Duong T, Mellett N, Cinel M, Mir SA, Chen L, Wenk MR, Karnani N, Collier F, Saffery R, Vuillermin P, Ponsonby AL, Burgner D, Meikle P.
Elife. 2022 Mar 2;11:e72779. doi: 10.7554/eLife.72779.

Lipidomic profiling of human serum enables detection of pancreatic cancer

Wolrab D, Jirásko R, Cífková E, Höring M, Ding Mei, Chocholoušková M, Peterka O, Idkowiak J, Hrnčiarová T, Kuchař L, Ahrends R, Brumarová R, Friedecký D, Vivo-Truyols G, Škrha P, Škrha J, Kučera R, Melichar B, Liebisch G, Burkhardt R, Wenk MR, Cazenave-Gassiot A, Karásek P, Novotný I, Greplová K, Hrstka R, Holčapek M.
Nature Communications, 2022, 13(1), 124. doi: 10.1038/s41467-021-27765-9. Epub 2022 Jan 10.

Variability of the Plasma Lipidome and Subclinical Coronary Atherosclerosis

Tan SH, Koh HWL, Chua JY, Burla B, Ong CC, Teo LSL, Yang X, Benke PI, Choi H, Torta F, Richards AM, Wenk MR, Chan MY.
Arterioscler Thromb Vasc Biol. 2022 Jan;42(1):100-112. doi: 10.1161/ATVBAHA.121.316847. Epub 2021 Nov 23.


Host/ Malassezia Interaction: A Quantitative, Non-Invasive Method Profiling Oxylipin Production Associates Human Skin Eicosanoids with Malassezia

Ambaw YA, Pagac MP, Irudayaswamy AS, Raida M, Bendt AK, Torta FT, Wenk MR, Dawson TL Jr.
Metabolites. 2021 Oct 13;11(10):700. doi: 10.3390/metabo11100700.

Recommendations for good practice in MS-based lipidomics

Köfeler HC, Ahrends R, Baker ES, Ekroos K, Han X, Hoffmann N, Holčapek M, Wenk MR, Liebisch G.
J Lipid Res. 2021;62:100138. doi: 10.1016/j.jlr.2021.100138. Epub 2021 Oct 16.

Fatty acid oxidation is a druggable gateway regulating cellular plasticity for driving metastasis in breast cancer

Loo SY, Toh LP, Xie WH, Pathak E, Tan W, Ma S, Lee MY, Shatishwaran S, Yeo JZZ, Yuan J, Ho YY, Peh EKL, Muniandy M, Torta F, Chan J, Tan TJ, Sim Y, Tan V, Tan B, Madhukumar P, Yong WS, Ong KW, Wong CY, Tan PH, Yap YS, Deng LW, Dent R, Foo R, Wenk MR, Lee SC, Ho YS, Lim EH, Tam WL.
Sci Adv. 2021 Oct 8;7(41):eabh2443. doi: 10.1126/sciadv.abh2443. Epub 2021 Oct 6.

Healthy Breastfeeding Infants Consume Different Quantities of Milk Fat Globule Membrane Lipids

George AD, Gay MCL, Selvalatchmanan J, Torta F, Bendt AK, Wenk MR, Murray K, Wlodek ME, Geddes DT.
Nutrients. 2021 Aug 25;13(9):2951. doi: 10.3390/nu13092951.

Tailored Polymer-Based Selective Extraction of Lipid Mediators from Biological Samples

Ambaw YA, Dahl SR, Chen Y, Greibrokk T, Lundanes E, Lazraq I, Shinde S, Selvalatchmanan J, Wenk MR, Sellergren B, Torta F.
Metabolites. 2021 Aug 13;11(8):539. doi: 10.3390/metabo11080539.

Sphingolipid metabolism during Toll-like receptor 4 (TLR4)-mediated macrophage activation.

Olona A, Hateley C, Muralidharan S, Wenk MR, Torta F, Behmoaras J.
Br J Pharmacol. 2021 Dec;178(23):4575-4587. doi: 10.1111/bph.15642. Epub 2021 Sep 2.

Lipidomic Analysis of Archival Pathology Specimens Identifies Altered Lipid Signatures in Ovarian Clear Cell Carcinoma.

Mir SA, Wong SBJ, Narasimhan K, Esther CWL, Ji S, Burla B, Wenk MR, Tan DSP, Bendt AK.
Metabolites. 2021 Sep 3;11(9):597. doi: 10.3390/metabo11090597.

Quality control requirements for the correct annotation of lipidomics data.

Köfeler HC, Eichmann TO, Ahrends R, Bowden JA, Danne-Rasche N, Dennis EA, Fedorova M, Griffiths WJ, Han X, Hartler J, Holčapek M, Jirásko R, Koelmel JP, Ejsing CS, Liebisch G, Ni Z, O’Donnell VB, Quehenberger O, Schwudke D, Shevchenko A, Wakelam MJO, Wenk MR, Wolrab D, Ekroos K.
Nat Commun. 2021 Aug 6;12(1):4771. doi: 10.1038/s41467-021-24984-y.

TDP-43 mediates SREBF2-regulated gene expression required for oligodendrocyte myelination

Ho WY, Chang JC, Lim K, Cazenave-Gassiot A, Nguyen AT, Foo JC, Muralidharan S, Viera-Ortiz A, Ong SJM, Hor JH, Agrawal I, Hoon S, Arogundade OA, Rodriguez MJ, Lim SM, Kim SH, Ravits J, Ng SY, Wenk MR, Lee EB, Tucker-Kellogg G, Ling SC.
J Cell Biol. 2021 Sep 6;220(9):e201910213. doi: 10.1083/jcb.201910213. Epub 2021 Aug 4.

Placental 13C-DHA metabolism and relationship with maternal BMI, glycemia and birthweight

Watkins OC, Selvam P, Appukuttan Pillai R, Cracknell-Hazra VKB, Yong HEJ, Sharma N, Cazenave-Gassiot A, Bendt AK, Godfrey KM, Lewis RM, Wenk MR, Chan SY.
Mol Med. 2021 Aug 6;27(1):84. doi:10.1186/s10020-021-00344-w.

A reference map of sphingolipids in murine tissues.

Muralidharan S, Shimobayashi M, Ji S, Burla B, Hall MN, Wenk MR, Torta F.
Cell Rep. 2021 Jun 15;35(11):109250. doi: 10.1016/j.celrep.2021.109250.

Mapping the distribution of double bond location isomers in lipids across mouse tissues.

Ren H, Triebl A, Muralidharan S, Wenk MR, Xia Y, Torta F.
Analyst. 2021 Jun 14;146(12):3899-3907. doi: 10.1039/d1an00449b.

A small-molecule Psora-4 acts as a caloric restriction mimetic to promote longevity in C. elegans.

Admasu TD, Barardo D, Ng LF, Batchu KC, Cazenave-Gassiot A, Wenk MR, Gruber J.
Geroscience. 2021 May 14. doi:10.1007/s11357-021-00374-6.

Deletion of Mfsd2b impairs thrombotic functions of platelets.

Chandrakanthan M, Nguyen TQ, Hasan Z, Muralidharan S, Vu TM, Li AWL, Le UTN, Thi Thuy Ha H, Baik SH, Tan SH, Foo JC, Wenk MR, Cazenave-Gassiot A, Torta F, Ong WY, Chan MYY, Nguyen LN.Nat Commun. 2021 Apr 16;12(1):2286. doi: 10.1038/s41467-021-22642-x. Pubmed

Single-Cell Analysis of Blood-Brain Barrier Response to Pericyte Loss.

Mäe MA, He L, Nordling S, Vazquez-Liebanas E, Nahar K, Jung B, Li X, Tan BC, Chin Foo J, Cazenave-Gassiot A, Wenk MR, Zarb Y, Lavina B, Quaggin SE, Jeansson M, Gu C, Silver DL, Vanlandewijck M, Butcher EC, Keller A, Betsholtz C.
Circ Res. 2021 Feb 19;128(4):e46-e62. doi: 10.1161/CIRCRESAHA.120.317473. Epub 2020 Dec 30.

LICAR: An Application for Isotopic Correction of Targeted Lipidomic Data Acquired with Class-Based Chromatographic Separations Using Multiple Reaction Monitoring.

Gao L, Ji S, Burla B, Wenk MR, Torta F, Cazenave-Gassiot A.
Anal Chem. 2021 Feb 16;93(6):3163-3171. doi: 10.1021/acs.analchem.0c04565. Epub 2021 Feb 3.

Dietary Fat and Protein Intake in Relation to Plasma Sphingolipids as Determined by a Large-Scale Lipidomic Analysis.

Seah JYH, Chew WS, Torta F, Khoo CM, Wenk MR, Herr DR, Tai ES, van Dam RM.
Metabolites. 2021 Feb 8;11(2):93. doi:10.3390/metabo11020093.

Variability of Lipids in Human Milk.

Selvalatchmanan J, Rukmini AV, Ji S, Triebl A, Gao L, Bendt AK, Wenk MR, Gooley JJ, Torta F.
Metabolites. 2021 Feb 11;11(2):104. doi: 10.3390/metabo11020104.


Remodeling of whole-body lipid metabolism and a diabetic-like phenotype caused by loss of CDK1 and hepatocyte division.

Ow JR, Cadez MJ, Zafer G, Foo JC, Li HY, Ghosh S, Wollmann H, Cazenave-Gassiot A, Ong CB, Wenk MR, Han W, Choi H, Kaldis P.
Elife. 2020 Dec 21;9:e63835. doi: 10.7554/eLife.63835.

Impact of ion suppression by sample cap liners in lipidomics.

Benke PI, Burla B, Ekroos K, Wenk MR, Torta F.
Anal Chim Acta. 2020 Nov 15;1137:136-142. doi: 10.1016/j.aca.2020.09.055. Epub 2020 Sep 29.

Coffee, Black Tea, and Green Tea Consumption in Relation to Plasma Metabolites in an Asian Population.

Seow WJ, Yanwen DL, Pan WC, Gunther SH, Sim X, Torta F, Herr DR, Kovalik JP, Jianhong C, Khoo CM, Wenk MR, Tai ES, van Dam RM.
Mol Nutr Food Res. 2020 Oct 29:e2000527. doi: 10.1002/mnfr.202000527. Online ahead of print.

Profile of tear lipid mediator as a biomarker of inflammation for meibomian gland dysfunction and ocular surface diseases: Standard operating procedures.

Ambaw YA, Timbadia DP, Raida M, Torta F, Wenk MR, Tong L.
Ocul Surf. 2020 Oct 3:S1542-0124(20)30148-8. doi: 10.1016/j.jtos.2020.09.008. Online ahead of print.

Immunomodulatory sphingosine-1-phosphates as plasma biomarkers of Alzheimer’s disease and vascular cognitive impairment.

Chua XY, Chai YL, Chew WS, Chong JR, Ang HL, Xiang P, Camara K, Howell AR, Torta F, Wenk MR, Hilal S, Venketasubramanian N, Chen CP, Herr DR, Lai MKP.
Alzheimers Res Ther. 2020 Sep 30;12(1):122. doi: 10.1186/s13195-020-00694-3.

MRMkit: Automated Data Processing for Large-Scale Targeted Metabolomics Analysis.

Teo G, Chew WS, Burla BJ, Herr D, Tai ES, Wenk MR, Torta F, Choi H.
Anal Chem. 2020 Oct 20;92(20):13677-13682. doi: 10.1021/acs.analchem.0c03060. Epub 2020 Sep 28.

Plasma sphingolipids and risk of cardiovascular diseases: a large-scale lipidomic analysis.

Seah JYH, Chew WS, Torta F, Khoo CM, Wenk MR, Herr DR, Choi H, Tai ES, van Dam RM.
Metabolomics. 2020 Aug 20;16(9):89. doi: 10.1007/s11306-020-01709-8.

The bacterial quorum sensing signal DSF hijacks Arabidopsis thaliana sterol biosynthesis to suppress plant innate immunity.

Tran TM, Ma Z, Triebl A, Nath S, Cheng Y, Gong BQ, Han X, Wang J, Li JF, Wenk MR, Torta F, Mayor S, Yang L, Miao Y.
Life Sci Alliance. 2020 Aug 11;3(10):e202000720. doi: 10.26508/lsa.202000720. Print 2020 Oct.

Changes of tear lipid mediators after eyelid warming or thermopulsation treatment for meibomian gland dysfunction.

Ambaw YA, Fuchs D, Raida M, Mazengia NT, Torta F, Wheelock CE, Wenk MR, Tong L.
Prostaglandins Other Lipid Mediat. 2020 Dec;151:106474. doi: 10.1016/j.prostaglandins.2020.106474. Epub 2020 Aug 9.

Plasma High Density Lipoprotein Small Subclass is Reduced in Alzheimer’s Disease Patients and Correlates with Cognitive Performance.

Pedrini S, Hone E, Gupta VB, James I, Teimouri E, Bush AI, Rowe CC, Villemagne VL, Ames D, Masters CL, Rainey-Smith S, Verdile G, Sohrabi HR, Raida MR, Wenk MR, Taddei K, Chatterjee P, Martins I, Laws SM, Martins RN; AIBL Research Group.
J Alzheimers Dis. 2020;77(2):733-744. doi: 10.3233/JAD-200291.

FasR Regulates Fatty Acid Biosynthesis and Is Essential for Virulence of Mycobacterium tuberculosis.

Mondino S, Vázquez CL, Cabruja M, Sala C, Cazenave-Gassiot A, Blanco FC, Wenk MR, Bigi F, Cole ST, Gramajo H, Gago G.
Front Microbiol. 2020 Oct 27;11:586285. doi: 10.3389/fmicb.2020.586285. eCollection 2020.

Lipidomics needs more standardization.

Lipidomics Standards Initiative Consortium.
Nat Metab. 2019 Aug;1(8):745-747. doi: 10.1038/s42255-019-0094-z.

Change of tear lipid mediators in a post-trabeculectomy cohort.

Ambaw YA, Wong T, Chong R, Ah H, Ji S, Raida M, Torta F, Wenk MR, Tong L.
Ocul Surf. 2020 Jul 2:S1542-0124(20)30101-4. doi: 10.1016/j.jtos.2020.06.004. Online ahead of print.

LipidCreator workbench to probe the lipidomic landscape.

Peng B, Kopczynski D, Pratt BS, Ejsing CS, Burla B, Hermansson M, Benke PI, Tan SH, Chan MY, Torta F, Schwudke D, Meckelmann SW, Coman C, Schmitz OJ, MacLean B, Manke MC, Borst O, Wenk MR, Hoffmann N, Ahrends R.
Nat Commun. 2020 Apr 28;11(1):2057. doi: 10.1038/s41467-020-15960-z.

Dual mass spectrometry as a tool to improve annotation and quantification in targeted plasma lipidomics.

Gao L, Cazenave-Gassiot A, Burla B, Wenk MR, Torta F.
Metabolomics. 2020 Apr 17;16(5):53. doi: 10.1007/s11306-020-01677-z.

Responsiveness of sphingosine phosphate lyase insufficiency syndrome to vitamin B6 cofactor supplementation.

Zhao P, Liu ID, Hodgin JB, Benke PI, Selva J, Torta F, Wenk MR, Endrizzi JA, West O, Ou W, Tang E, Goh DL, Tay SK, Yap HK, Loh A, Weaver N, Sullivan B, Larson A, Cooper MA, Alhasan K, Alangari AA, Salim S, Gumus E, Chen K, Zenker M, Hildebrandt F, Saba JD.
J Inherit Metab Dis. 2020 Mar 31. doi: 10.1002/jimd.12238. Online ahead of print.

Origin of the mechanism of phenotypic plasticity in satyrid butterfly eyespots.

Bhardwaj S, Jolander LS, Wenk MR, Oliver JC, Nijhout HF, Monteiro A.
Elife. 2020 Feb 11;9:e49544. doi: 10.7554/eLife.49544.

Concurrent lipidomics and proteomics on malignant plasma cells from multiple myeloma patients: Probing the lipid metabolome.

Mohamed A, Collins J, Jiang H, Molendijk J, Stoll T, Torta F, Wenk MR, Bird RJ, Marlton P, Mollee P, Markey KA, Hill MM.
PLoS One. 2020 Jan 8;15(1):e0227455. doi: 10.1371/journal.pone.0227455. eCollection 2020.

Activation of sphingosine 1-phosphate receptor 2 attenuates chemotherapy-induced neuropathy.

Wang W, Xiang P, Chew WS, Torta F, Bandla A, Lopez V, Seow WL, Lam BWS, Chang JK, Wong P, Chayaburakul K, Ong WY, Wenk MR, Sundar R, Herr DR.
J Biol Chem. 2020 Jan 24;295(4):1143-1152. doi: 10.1074/jbc.RA119.011699. Epub 2019 Dec 27.

Long acyl chain ceramides govern cholesterol and cytoskeleton dependence of membrane outer leaflet dynamics.

Gupta A, Muralidharan S, Torta F, Wenk MR, Wohland T.
Biochim Biophys Acta Biomembr. 2020 Mar 1;1862(3):183153. doi: 10.1016/j.bbamem.2019.183153. Epub 2019 Dec 16.

Shared reference materials harmonize lipidomics across MS-based detection platforms and laboratories.

Triebl A, Burla B, Selvalatchmanan J, Oh J, Tan SH, Chan MY, Mellet NA, Meikle PJ, Torta F, Wenk MR.
J Lipid Res. 2020 Jan;61(1):105-115. doi: 10.1194/jlr.D119000393. Epub 2019 Nov 15.


Lipidomics needs more standardization.

Lipidomics Standards Initiative Consortium: Gerhard Liebisch, Robert Ahrends, Makoto Arita, Masanori Arita, John A Bowden, Christer S Ejsing, William J Griffiths, Michal Holčapek, Harald Köfeler, Todd W Mitchell, Markus R Wenk, Kim Ekroos.
Nat Metab. 2019 Aug;1(8):745-747. doi: 10.1038/s42255-019-0094-z.

Serum lipidome analysis of healthy beagle dogs receiving different diets.

Boretti FS, Burla B, Deuel J, Gao L, Wenk MR, Liesegang A, Sieber-Ruckstuhl NS.
Metabolomics. 2019 Dec 3;16(1):1. doi: 10.1007/s11306-019-1621-3.

Movement of accessible plasma membrane cholesterol by the GRAMD1 lipid transfer protein complex.

Naito T, Ercan B, Krshnan L, Triebl A, Koh DHZ, Wei FY, Tomizawa K, Torta FT, Wenk MR, Saheki Y.
Elife. 2019 Nov 14;8:e51401. doi: 10.7554/eLife.51401.

Associations with metabolites in Chinese suggest new metabolic roles in Alzheimer’s and Parkinson’s diseases.

Chai JF, Raichur S, Khor IW, Torta F, Chew WS, Herr DR, Ching J, Kovalik JP, Khoo CM, Wenk MR, Tai ES, Sim X.
Hum Mol Genet. 2020 Jan 15;29(2):189-201. doi: 10.1093/hmg/ddz246.

Metabolic stress is a primary pathogenic event in transgenic Caenorhabditis elegans expressing pan-neuronal human amyloid beta.

Teo E, Ravi S, Barardo D, Kim HS, Fong S, Cazenave-Gassiot A, Tan TY, Ching J, Kovalik JP, Wenk MR, Gunawan R, Moore PK, Halliwell B, Tolwinski N, Gruber J.
Elife. 2019 Oct 15;8:e50069. doi: 10.7554/eLife.50069.

Myo-inositol alters 13C-labeled fatty acid metabolism in human placental explants.

Watkins OC, Islam MO, Selvam P, Pillai RA, Cazenave-Gassiot A, Bendt AK, Karnani N, Godfrey KM, Lewis RM, Wenk MR, Chan SY.
J Endocrinol. 2019 Aug 1. pii: JOE-19-0267.R1. doi: 10.1530/JOE-19-0267. [Epub ahead of print]

Gains and losses of metabolic function inferred from a phylotranscriptomic analysis of algae.

Goh FQY, Jeyakani J, Tipthara P, Cazenave-Gassiot A, Ghosh R, Bogard N, Yeo Z, Wong GK, Melkonian M, Wenk MR, Clarke ND.
Sci Rep. 2019 Jul 19;9(1):10482. doi: 10.1038/s41598-019-46869-3.

A T164S mutation in the dengue virus NS1 protein is associated with greater disease severity in mice.

Chan KWK, Watanabe S, Jin JY, Pompon J, Teng D, Alonso S, Vijaykrishna D, Halstead SB, Marzinek JK, Bond PJ, Burla B, Torta F, Wenk MR, Ooi EE, Vasudevan SG.
Sci Transl Med. 2019 Jun 26;11(498). pii: eaat7726. doi: 10.1126/scitranslmed.aat7726.

Tackling the Complexity of the Exposome: Considerations from the Gunma University Initiative for Advanced Research (GIAR) Exposome Symposium.

Zhang P, Arora M, Chaleckis R, Isobe T, Jain M, Meister I, Melén E, Perzanowski M, Torta F, Wenk MR, Wheelock CE.
Metabolites. 2019 Jun 6;9(6). pii: E106. doi: 10.3390/metabo9060106.

Large-scale lipidomics identifies associations between plasma sphingolipids and T2DM incidence.

Chew WS, Torta F, Ji S, Choi H, Begum H, Sim X, Khoo CM, Khoo EYH, Ong WY, Van Dam RM, Wenk MR, Tai ES, Herr DR.
JCI Insight. 2019 Jun 4;5. pii: 126925. doi: 10.1172/jci.insight.126925.

Protective Function of Mitogen-Activated Protein Kinase Phosphatase 5 in Aging- and Diet-Induced Hepatic Steatosis and Steatohepatitis.

Tang P, Low HB, Png CW, Torta F, Kumar JK, Lim HY, Zhou Y, Yang H, Angeli V, Shabbir A, Tai ES, Flavell RA, Dong C, Wenk MR, Yang DY, Zhang Y.
Hepatol Commun. 2019 Mar 1;3(6):748-762. doi: 10.1002/hep4.1324. eCollection 2019 Jun.

The Lysophosphatidylcholine Transporter MFSD2A Is Essential for CD8+ Memory T Cell Maintenance and Secondary Response to Infection.

Piccirillo AR Hyzny EJ, Beppu LY, Menk AV, Wallace CT, Hawse WF, Buechel HM1, Wong BH, Foo JC, Cazenave-Gassiot A, Wenk MR, Delgoffe GM, Watkins SC, Silver DL, D’Cruz LM.
J Immunol. 2019 May 24. pii: ji1801585. doi: 10.4049/jimmunol.1801585. [Epub ahead of print]

Halted Lymphocyte Egress via Efferent Lymph Contributes to Lymph Node Hypertrophy During Hypercholesterolemia.

Tay MHD, Lim SYJ, Leong YFI, Thiam CH, Tan KW, Torta FT, Narayanaswamy P, Wenk M, Angeli V.
Front Immunol. 2019 Mar 27;10:575. doi: 10.3389/fimmu.2019.00575. eCollection 2019.

Time-resolved small-angle neutron scattering as a probe for the dynamics of lipid exchange between human lipoproteins and naturally derived membranes.

Maric S, Lind TK, Raida MR, Bengtsson E, Fredrikson GN, Rogers S, Moulin M, Haertlein M, Forsyth VT, Wenk MR, Pomorski TG, Arnebrant T, Lund R, Cárdenas M.
Sci Rep. 2019 May 20;9(1):7591. doi: 10.1038/s41598-019-43713-6.

Changes in the Canine Plasma Lipidome after Short- and Long-Term Excess Glucocorticoid Exposure.

Sieber-Ruckstuhl NS, Burla B, Spoerel S, Schmid F, Venzin C, Cazenave-Gassiot A, Bendt AK, Torta F, Wenk MR, Boretti FS.
Sci Rep. 2019 Apr 12;9(1):6015. doi: 10.1038/s41598-019-42190-1.

Metabolism of 13C-labeled fatty acids in term human placental explants by liquid chromatography mass spectrometry.

Watkins OC, Islam MO, Selvam P, Pillai RA, Cazenave-Gassiot A, Bendt AK, Karnani N, Godfrey KM, Lewis RM, Wenk MR, Chan SY.
Endocrinology. 2019 Mar 28. pii: en.2018-01020. doi: 10.1210/en.2018-01020. [Epub ahead of print]

Assessment of diets containing curcumin, epigallocatechin-3-gallate, docosahexaenoic acid and α-lipoic acid on amyloid load and inflammation in a male transgenic mouse model of Alzheimer’s disease: Are combinations more effective?

Sharman MJ, Gyengesi E, Liang H, Chatterjee P, Karl T, Li QX, Wenk MR, Halliwell B, Martins RN, Müench G.
Neurobiol Dis. 2019 Jan 2. pii: S0969-9961(18)30770-8. doi: 10.1016/j.nbd.2018.11.026. [Epub ahead of print]


Pharmacokinetics of Prenylflavonoids following Oral Ingestion of Standardized Epimedium Extract in Humans.

Teo YL, Cheong WF, Cazenave-Gassiot A, Ji S, Logan S, Lee ZXK, Li J, Seng KY, Lee LS, Yong EL.
Planta Med. 2018 Dec 6. doi: 10.1055/a-0806-7673. [Epub ahead of print]

Analytical Considerations of Stable Isotope Labelling in Lipidomics.

Triebl A, Wenk MR
Biomolecules. 2018 Nov 16;8(4). pii: E151. doi: 10.3390/biom8040151.

Lipid profiling of C. elegans strains administered pro-longevity drugs and drug combinations.

Admasu TD, Batchu KC, Ng LF, Cazenave-Gassiot A, Wenk MR, Gruber J.
Sci Data. 2018 Oct 23;5:180231. doi: 10.1038/sdata.2018.231.

Identification of mycolic acid forms using surface-enhanced Raman scattering as a fast detection method for tuberculosis.

Perumal J, Dinish US, Bendt AK, Kazakeviciute A, Fu CY, Ong ILH, Olivo M.
Int J Nanomedicine. 2018 Oct 4;13:6029-6038. doi: 10.2147/IJN.S171400. eCollection 2018.

Synthetic Enzymology and the Fountain of Youth: Repurposing Biology for Longevity.

Lim YP, Go MK, Raida M, Inoue T, Wenk MR, Keasling JD, Chang MW, Yew WS.
ACS Omega. 2018 Sep 30;3(9):11050-11061. doi: 10.1021/acsomega.8b01620. Epub 2018 Sep 12.

Drug Synergy Slows Aging and Improves Healthspan through IGF and SREBP Lipid Signaling.

Admasu TD, Chaithanya Batchu K, Barardo D, Ng LF, Lam VYM, Xiao L, Cazenave-Gassiot A, Wenk MR, Tolwinski NS, Gruber J.
Dev Cell. 2018 Sep 24. pii: S1534-5807(18)30699-3. doi: 10.1016/j.devcel.2018.09.001. [Epub ahead of print]

MS-based lipidomics of human blood plasma – a community-initiated position paper to develop accepted guidelines.

Burla, B; Arita, M; Arita, M; Bendt, AK; Cazenave-Gassiot, A; Dennis, EA; Ekroos, K; Han X; Ikeda, K; Liebisch, G; Lin, MK, Loh, TP; Meikle, PJ; Orešič, M; Quehenberger, O; Shevchenko, A; Torta, F; Wakelam, MJO; Wheelock, CE; Wenk, MR.
J Lipid Res. 2018 Oct;59(10):2001-2017. doi: 10.1194/jlr.S087163.

The lysolipid transporter Mfsd2a regulates lipogenesis in the developing brain.

Chan, JP; Wong, BH; Chin, CF; Galam, DLA; Foo, JC; Wong, LC; Ghosh S; Wenk, MR; Cazenave-Gassiot A; Silver, DL
PLoS Biol. 2018 Aug 3;16(8):e2006443. doi: 10.1371/journal.pbio.2006443. eCollection 2018 Aug.

Tear eicosanoids in healthy people and ocular surface disease.

Ambaw YA, Chao C, Ji S, Raida M, Torta F, Wenk MR, Tong L
Sci Rep. 2018 Jul 26;8(1):11296. doi: 10.1038/s41598-018-29568-3.

Homozygous mutation in MFSD2A, encoding a lysolipid transporter for docosahexanoic acid, is associated with microcephaly and hypomyelination.

Harel T, Quek DQY, Wong BH, Cazenave-Gassiot A, Wenk MR, Fan H, Berger I, Shmueli D, Shaag A, Silver DL, Elpeleg O, Edvardson S.
Neurogenetics. 2018 Jul 24. doi: 10.1007/s10048-018-0556-6. [Epub ahead of print]

The Iceman’s Last Meal Consisted of Fat, Wild Meat, and Cereals.

Maixner F, Turaev D, Cazenave-Gassiot A, Janko M, Krause-Kyora B, Hoopmann MR, Kusebauch U, Sartain M, Guerriero G, O’Sullivan N, Teasdale M, Cipollini G, Paladin A, Mattiangeli V, Samadelli M, Tecchiati U, Putzer A, Palazoglu M, Meissen J, Lösch S, Rausch P, Baines JF, Kim BJ, An HJ, Gostner P, Egarter-Vigl E, Malfertheiner P, Keller A, Stark RW, Wenk M, Bishop D, Bradley DG, Fiehn O, Engstrand L, Moritz RL, Doble P, Franke A, Nebel A, Oeggl K, Rattei T, Grimm R, Zink A.
Curr Biol. 2018 Jul 23;28(14):2348-2355.e9. doi: 10.1016/j.cub.2018.05.067.

A novel vibration-induced exercise paradigm improves fitness and lipid metabolism of Caenorhabditis elegans.

Teo E, Batchu KC, Barardo D, Xiao L, Cazenave-Gassiot A, Tolwinski N, Wenk M, Halliwell B, Gruber J.
Sci Rep. 2018 Jun 20;8(1):9420. doi: 10.1038/s41598-018-27330-3.

Sphingolipidomics analysis of large clinical cohorts. Part 1: Technical notes and practical considerations.

Chew WS, Seow WL, Chong JR, Lai MKP, Torta F, Wenk MR, Herr DR.
Biochem Biophys Res Commun. 2018 Apr 18. pii: S0006-291X(18)30845-3. doi: 10.1016/j.bbrc.2018.04.076. [Epub ahead of print]

LRH-1 regulates hepatic lipid homeostasis and maintains arachidonoyl phospholipid pools critical for phospholipid diversity.

Miranda DA, Krause WC, Cazenave-Gassiot A, Suzawa M, Escusa H, Foo JC, Shihadih DS, Stahl A, Fitch M, Nyangau E, Hellerstein M, Wenk MR, Silver DL, Ingraham HA.
JCI Insight. 2018 Mar 8;3(5). pii: 96151. doi: 10.1172/jci.insight.96151.

Sphingolipid Analysis in Clinical Research

Burla B, Muralidharan S, Wenk MR, Torta F.
Methods Mol Biol. 2018;1730:135-162. doi: 10.1007/978-1-4939-7592-1_11.

Terminology of bioanalytical methods. (IUPAC Recommendations 2018)

Labuda J, Bowater RP, Fojta M, Gauglitz G, Glatz Z, Hapala I, Havliš J, Kilar F, Kilar A, Malinovská L, Sirén HMM, Skládal P, Torta F, Valachovič M, Wimmerová M, Zdráhal Z, Hibbert DB
Pure Appl. Chem. 2018; 90(7): 1121–1198. doi: 10.1515/pac-2016-1120


Using lipidomics to reveal details of lipid accumulation in developing seeds from oilseed rape ( Brassica napus L.).

Woodfield HK, Cazenave-Gassiot A, Haslam RP, Guschina IA, Wenk MR, Harwood JL.
Biochim. Biophys. Acta – Mol. Cell Biol. Lipids. (2017). doi:10.1016/j.bbalip.2017.12.010.

Sex differences in 20-hydroxyecdysone hormone levels control sexual dimorphism in Bicyclus anynana wing patterns.

Bhardwaj S, Prudic KL, Bear A, Gupta MD, Wasik BR, Tong X, Cheong WF, Wenk MR, Monteiro A.
Mol Biol Evol. 2017 Nov 20. doi: 10.1093/molbev/msx301.

Deciphering lipid structures based on platform-independent decision rules.

Hartler J, Triebl A, Ziegl A, Trötzmüller M, Rechberger GN, Zeleznik OA, Zierler KA, Torta F, Cazenave-Gassiot A, Wenk MR, Fauland A, Wheelock CE, Armando AM, Quehenberger O, Zhang Q Wakelam MJO, Hämmerle G, Spener F, Köfeler HC, Thallinger GG.
Nat Methods. 2017 Oct 23. doi: 10.1038/nmeth.4470.

Mfsd2b is essential for the sphingosine-1-phosphate export in erythrocytes and platelets.

Vu TM, Ishizu AN, Foo JC, Toh XR, Zhang F, Whee DM, Torta F, Cazenave-Gassiot A, Matsumura T, Kim S, Toh SES, Suda T, Silver DL, Wenk MR, Nguyen LN.
Nature. 2017 Oct 18. doi: 10.1038/nature24053.

Curcumin Ameliorates Neuroinflammation, Neurodegeneration, and Memory Deficits in p25 Transgenic Mouse Model that Bears Hallmarks of Alzheimer’s Disease.

Sundaram JR, Poore CP, Sulaimee NHB, Pareek T, Cheong WF, Wenk MR, Pant HC, Frautschy SA, Low CM, Kesavapany S.
J Alzheimers Dis. 2017 Oct 12. doi: 10.3233/JAD-170093.

Harmonizing Lipidomics: NIST Interlaboratory Comparison Exercise for Lipidomics using Standard Reference Material 1950 Metabolites in Frozen Human Plasma.

Bowden JA, Heckert A, Ulmer CZ, Jones CM, Koelmel JP, Abdullah L, Ahonen L, Alnouti Y, Armando A, Asara JM, Bamba T, Barr JR, Bergquist J, Borchers CH, Brandsma J, Breitkopf SB, Cajka T, Cazenave-Gassiot A, Checa A, Cinel MA, Colas RA, Cremers S, Dennis EA, Evans JE, Fauland A, Fiehn O, Gardner MS, Garrett TJ, Gotlinger KH, Han J, Huang Y, Neo AH, Hyotylainen T, Izumi Y, Jiang H, Jiang H, Jiang J, Kachman M, Kiyonami R, Klavins K, Klose C, Kofeler HC, Kolmert J, Koal T, Koster G, Kuklenyik Z, Kurland IJ, Leadley M, Lin K, Maddipati KR, McDougall D, Meikle PJ, Mellett NA, Monnin C, Moseley MA, Nandakumar R, Oresic M, Patterson RE, Peake D, Pierce JS, Post M, Postle AD, Pugh R, Qui Y, Quehenberger O, Ramrup P, Rees J, Rembiesa B, Reynaud D, Roth MR, Sales S, Schuhmann K, Schwartzman ML, Serhan CN, Shevchenko A, Somerville SE, John-Williams LS, Surma MA, Takeda H, Thakare R, Thompson JW, Torta F, Triebl A, Trötzmüller M, Ubhayasekera SJK, Vuckovic D, Weir JM, Welti R, Wenk MR, Wheelock CE, Yao L, Yuan M, Zhao XH, Zhou S.
J Lipid Res. 2017 Oct 6. pii: jlr.M079012. doi: 10.1194/jlr.M079012.

Establishing multiple omics baselines for three Southeast Asian populations in the Singapore Integrative Omics Study.

Saw WY, Tantoso E, Begum H, Zhou L, Zou R, He C, Chan SL, Tan LW, Wong LP, Xu W, Moong DKN, Lim Y, Li B, Pillai NE, Peterson TA, Bielawny T, Meikle PJ, Mundra PA, Lim WY, Luo M, Chia KS, Ong RT, Brunham LR, Khor CC, Too HP, Soong R, Wenk MR, Little P, Teo YY.
Nat Commun. 2017 Sep 21;8(1):653. doi: 10.1038/s41467-017-00413-x.

ABCA8 Regulates Cholesterol Efflux and High-Density Lipoprotein Cholesterol Levels.

Trigueros-Motos L, van Capelleveen JC, Torta F, Castaño D, Zhang LH, Chai C, Kang M, Dimova LG, Schimmel AWM, Tietjen I, Radomski C, Tan LJ, Hwee TC, Narayanaswamy P, Wu D, Dorninger F, Yakala GK, Barhdadi A, Angeli V, Dubé MP, Berger J, Dallinga-Thie GM, Tietge UJF, Wenk MR, Hayden MR, Hovingh GK, Singaraja RR.
Arterioscler Thromb Vasc Biol. 2017 Sep 7. pii: ATVBAHA.117.309574. doi: 10.1161/ATVBAHA.117.309574.

Global Mapping of Protein-Lipid Interactions by Using Modified Choline-Containing Phospholipids Metabolically Synthesized in Live Cells.

Wang D, Du S, Cazenave-Gassiot A, Ge J, Lee JS, Wenk MR, Yao SQ.
Angew Chem Int Ed Engl. 2017 Apr 21. doi: 10.1002/anie.201702509.

Comprehensive analysis of phospholipids and glycolipids in the opportunistic pathogen Enterococcus faecalis.

Rashid R, Cazenave-Gassiot A, Gao IH, Nair ZJ, Kumar JK, Gao L, Kline KA, Wenk MR.
PLoS One. 2017 Apr 19;12(4):e0175886. doi: 10.1371/journal.pone.0175886. eCollection 2017.

Hypoxia enhances antibody-dependent dengue virus infection.

Gan ES, Cheong WF, Chan KR, Ong EZ, Chai X, Tan HC, Ghosh S, Wenk MR, Ooi EE.
EMBO J. 2017 Mar 20. pii: e201695642. doi: 10.15252/embj.201695642.

Lipid transport by TMEM24 at ER-plasma membrane contacts regulates pulsatile insulin secretion.

Lees JA, Messa M, Sun EW, Wheeler H, Torta F, Wenk MR, De Camilli P, Reinisch KM.
Science. 2017 Feb 17;355(6326). pii: eaah6171. doi: 10.1126/science.aah6171.

A mutation of EPT1 (SELENOI) underlies a new disorder of Kennedy pathway phospholipid biosynthesis.

Ahmed MY, Al-Khayat A, Al-Murshedi F, Al-Futaisi A, Chioza BA, Pedro Fernandez-Murray J, Self JE, Salter CG, Harlalka GV, Rawlins LE, Al-Zuhaibi S, Al-Azri F, Al-Rashdi F, Cazenave-Gassiot A, Wenk MR, Al-Salmi F, Patton MA, Silver DL, Baple EL, McMaster CR, Crosby AH.

Brain. 2017 Jan 3;140(3):547-554.


Characterization of a dynamic metabolon producing the defense compound dhurrin in sorghum.

Laursen T, Borch J, Knudsen C, Bavishi K, Torta F, Martens HJ, Silvestro D, Hatzakis NS, Wenk MR, Dafforn TR, Olsen CE, Motawia MS, Hamberger B, Møller BL, Bassard JE.

Science. 2016 Nov 18;354(6314):890-893.

Role of prefrontal cortical calcium-independent phospholipase A2 in antinociceptive effect of the norepinephrine reuptake inhibitor antidepresssant maprotiline.

Chew WS, Shalini SM, Torta F, Wenk MR, Stohler C, Yeo JF, Herr DR, Ong WY.

Neuroscience. 2017 Jan 6;340:91-100.

Activity-Based Lipid Esterase Profiling of M. bovis BCG at Different Metabolic States Using Tetrahydrolipstatin (THL) as Bait.

Ravindran MS, Wenk MR.

Methods Mol Biol. 2017;1491:75-85.

Defining key roles for auxiliary proteins in an ABC transporter that maintains bacterial outer membrane lipid asymmetry.

Thong S, Ercan B, Torta F, Fong ZY, Wong HY, Wenk MR, Chng SS.

Elife. 2016 Aug 16;5.

Lipid-Based Therapy for Ocular Surface Inflammation and Disease.

Lim A, Wenk MR, Tong L.

Trends Mol Med. 2016 Jul;22(7):629.

Aberrant expression of the S1P regulating enzymes, SPHK1 and SGPL1, contributes to a migratory phenotype in OSCC mediated through S1PR2.

Patmanathan SN, Johnson SP, Lai SL, Panja Bernam S, Lopes V, Wei W, Ibrahim MH, Torta F, Narayanaswamy P, Wenk MR, Herr DR, Murray PG, Yap LF, Paterson IC.

Sci Rep. 2016 May 10;6:25650.

Mfsd2a Is a Transporter for the Essential ω-3 Fatty Acid Docosahexaenoic Acid (DHA) in Eye and Is Important for Photoreceptor Cell Development.

Wong BH, Chan JP, Cazenave-Gassiot A, Poh RW, Foo JC, Galam DL, Ghosh S, Nguyen LN, Barathi VA, Yeo SW, Luu CD, Wenk MR, Silver DL.

J Biol Chem. 2016 May 13;291(20):10501-14.

Sphingosine kinase inhibition ameliorates chronic hypoperfusion-induced white matter lesions.

Yang Y, Torta F, Arai K, Wenk MR, Herr DR, Wong PT, Lai MK.

Neurochem Int. 2016 Mar;94:90-7.

Plasma Phospholipid and Sphingolipid Alterations in Presenilin1 Mutation Carriers: A Pilot Study.

Chatterjee P, Lim WL, Shui G, Gupta VB, James I, Fagan AM, Xiong C, Sohrabi HR, Taddei K, Brown BM, Benzinger T, Masters C, Snowden SG, Wenk MR, Bateman RJ, Morris JC, Martins RN.

J Alzheimers Dis. 2016;50(3):887-94.

Discovering and validating between-subject variations in plasma lipids in healthy subjects.

Begum H, Li B, Shui G, Cazenave-Gassiot A, Soong R, Ong RT, Little P, Teo YY, Wenk MR.

Sci Rep. 2016 Jan 8;6:19139.


Ceramides And Stress Signalling Intersect With Autophagic Defects In Neurodegenerative Drosophila blue cheese (bchs) Mutants.

Hebbar S, Sahoo I, Matysik A, Argudo Garcia I, Osborne KA, Papan C, Torta F, Narayanaswamy P, Fun XH, Wenk MR, Shevchenko A, Schwudke D, Kraut R.

Sci Rep. 2015 Dec 7;5:15926.

Lipid-Based Therapy for Ocular Surface Inflammation and Disease.

Lim A, Wenk MR, Tong L.

Trends Mol Med. 2015 Dec;21(12):736-48.

Differential Expression of Ecdysone Receptor Leads to Variation in Phenotypic Plasticity across Serial Homologs.

Monteiro A, Tong X, Bear A, Liew SF, Bhardwaj S, Wasik BR, Dinwiddie A, Bastianelli C, Cheong WF, Wenk MR, Cao H, Prudic KL.

PLoS Genet. 2015 Sep 25;11(9):e1005529.

Arabidopsis AtPLC2 Is a Primary Phosphoinositide-Specific Phospholipase C in Phosphoinositide Metabolism and the Endoplasmic Reticulum Stress Response.

Kanehara K, Yu CY, Cho Y, Cheong WF, Torta F, Shui G, Wenk MR, Nakamura Y.

PLoS Genet. 2015 Sep 24;11(9):e1005511.

The fusogenic lipid phosphatidic acid promotes the biogenesis of mitochondrial outer membrane protein Ugo1.

Vögtle FN, Keller M, Taskin AA, Horvath SE, Guan XL, Prinz C, Opalińska M, Zorzin C, van der Laan M, Wenk MR, Schubert R, Wiedemann N, Holzer M, Meisinger C.

J Cell Biol. 2015 Sep 14;210(6):951-60.

INTRACELLULAR TRANSPORT. PI4P/phosphatidylserine countertransport at ORP5- and ORP8-mediated ER-plasma membrane contacts.

Chung J, Torta F, Masai K, Lucast L, Czapla H, Tanner LB, Narayanaswamy P, Wenk MR, Nakatsu F, De Camilli P.

Science. 2015 Jul 24;349(6246):428-32.

Changes in Plasma Lipids during Exposure to Total Sleep Deprivation.

Chua EC, Shui G, Cazenave-Gassiot A, Wenk MR, Gooley JJ.

Sleep. 2015 Nov 1;38(11):1683-91.

Phosphatidic acid is a major phospholipid class in reproductive organs of Arabidopsis thaliana.

Yunus IS, Cazenave-Gassiot A, Liu YC, Lin YC, Wenk MR, Nakamura Y.

Plant Signal Behav. 2015;10(8):e1049790.

Co-option of Membrane Wounding Enables Virus Penetration into Cells.

Luisoni S, Suomalainen M, Boucke K, Tanner LB, Wenk MR, Guan XL, Grzybek M, Coskun Ü, Greber UF.

Cell Host Microbe 2015 Jul 8;18(1):75-85.

The Lipid-Modifying Enzyme SMPDL3B Negatively Regulates Innate Immunity.

Heinz LX, Baumann CL, Köberlin MS, Snijder B, Gawish R, Shui G, Sharif O, Aspalter IM, Müller AC, Kandasamy RK, Breitwieser FP, Pichlmair A, Bruckner M, Rebsamen M, Blüml S, Karonitsch T, Fauster A, Colinge J, Bennett KL, Knapp S, Wenk MR, Superti-Furga G.

Cell Rep. 2015 Jun 30;11(12):1919-28.

Inactivating mutations in MFSD2A, required for omega-3 fatty acid transport in brain, cause a lethal microcephaly syndrome.

Guemez-Gamboa A, Nguyen LN, Yang H, Zaki MS, Kara M, Ben-Omran T, Akizu N, Rosti RO, Rosti B, Scott E, Schroth J, Copeland B, Vaux KK, Cazenave-Gassiot A, Quek DQ, Wong BH, Tan BC, Wenk MR, Gunel M, Gabriel S, Chi NC, Silver DL, Gleeson JG.

Nat Genet. 2015 Jul;47(7):809-13.

A partially inactivating mutation in the sodium-dependent lysophosphatidylcholine transporter MFSD2A causes a non-lethal microcephaly syndrome.

Alakbarzade V, Hameed A, Quek DQ, Chioza BA, Baple EL, Cazenave-Gassiot A, Nguyen LN, Wenk MR, Ahmad AQ, Sreekantan-Nair A, Weedon MN, Rich P, Patton MA, Warner TT, Silver DL, Crosby AH.

Nat Genet. 2015 Jul;47(7):814-7.

The diagnostic targeting of a carbohydrate virulence factor from M.Tuberculosis.

Chan CE, Götze S, Seah GT, Seeberger PH, Tukvadze N, Wenk MR, Hanson BJ, MacAry PA.

Sci Rep. 2015 May 15;5:10281.


Rhinovirus uses a phosphatidylinositol 4-phosphate/cholesterol counter-current for the formation of replication compartments at the ER-Golgi interface.

Roulin PS, Lötzerich M, Torta F, Tanner LB, van Kuppeveld FJ, Wenk MR, Greber UF.

Cell Host Microbe. 2014 Nov 12;16(5):677-90.

Lipidomics and genomics of Mycobacterium tuberculosis reveal lineage-specific trends in mycolic acid biosynthesis.

Portevin D, Sukumar S, Coscolla M, Shui G, Li B, Guan XL, Bendt AK, Young D, Gagneux S, Wenk MR.

Microbiologyopen. 2014 Dec;3(6):823-35.

A semi-automated methodology for finding lipid-related GO terms.

Fan M, Low HS, Wenk MR, Wong L.

Database (Oxford). 2014 Sep 10;2014. pii: bau089.

Longitudinal changes in tear fluid lipidome brought about by eyelid-warming treatment in a cohort of meibomian gland dysfunction.

Lam SM, Tong L, Duan X, Acharya UR, Tan JH, Petznick A, Wenk MR, Shui G.

J Lipid Res. 2014 Sep;55(9):1959-69.

Comprehensive analysis of lipid composition in crude palm oil using multiple lipidomic approaches.

Cheong WF, Wenk MR, Shui G.

J Genet Genomics. 2014 May 20;41(5):293-304.

Lipidomics identifies a requirement for peroxisomal function during influenza virus replication.

Tanner LB, Chng C, Guan XL, Lei Z, Rozen SG, Wenk MR.

J Lipid Res. 2014 Jul;55(7):1357-65.

Structure of a lipid-bound extended synaptotagmin indicates a role in lipid transfer.

Schauder CM, Wu X, Saheki Y, Narayanaswamy P, Torta F, Wenk MR, De Camilli P, Reinisch KM.

Nature. 2014 Jun 26;510(7506):552-5.

Insights into the genetic structure and diversity of 38 South Asian Indians from deep whole-genome sequencing.

Wong LP, Lai JK, Saw WY, Ong RT, Cheng AY, Pillai NE, Liu X, Xu W, Chen P, Foo JN, Tan LW, Koo SH, Soong R, Wenk MR, Lim WY, Khor CC, Little P, Chia KS, Teo YY.

PLoS Genet. 2014 May 15;10(5):e1004377.

Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid.

Nguyen LN, Ma D, Shui G, Wong P, Cazenave-Gassiot A, Zhang X, Wenk MR, Goh EL, Silver DL.

Nature. 2014 May 22;509(7501):503-6.

Brain lipidomes of subcortical ischemic vascular dementia and mixed dementia.

Lam SM, Wang Y, Duan X, Wenk MR, Kalaria RN, Chen CP, Lai MK, Shui G.

Neurobiol Aging. 2014 Oct;35(10):2369-81.

Transcriptomic and lipidomic profiles of glycerolipids during Arabidopsis flower development.

Nakamura Y, Teo NZ, Shui G, Chua CH, Cheong WF, Parameswaran S, Koizumi R, Ohta H, Wenk MR, Ito T.

New Phytol. 2014 Jul;203(1):310-22. 24684726

Evaluation of dietary effects on hepatic lipids in high fat and placebo diet fed rats by in vivo MRS and LC-MS techniques.

Yaligar J, Gopalan V, Kiat OW, Sugii S, Shui G, Lam BD, Henry CJ, Wenk MR, Tai ES, Velan SS.

PLoS One. 2014 Mar 17;9(3):e91436.

The mitochondria-targeted antioxidant MitoQ extends lifespan and improves healthspan of a transgenic Caenorhabditis elegans model of Alzheimer disease.

Ng LF, Gruber J, Cheah IK, Goo CK, Cheong WF, Shui G, Sit KP, Wenk MR, Halliwell B.

Free Radic Biol Med. 2014 Jun;71:390-401.

Genome profiling of sterol synthesis shows convergent evolution in parasites and guides chemotherapeutic attack.

Fügi MA, Gunasekera K, Ochsenreiter T, Guan X, Wenk MR, Mäser P.

J Lipid Res. 2014 May;55(5):929-38.

Caveolae regulate the nanoscale organization of the plasma membrane to remotely control Ras signaling.

Ariotti N, Fernández-Rojo MA, Zhou Y, Hill MM, Rodkey TL, Inder KL, Tanner LB, Wenk MR, Hancock JF, Parton RG.

J Cell Biol. 2014 Mar 3;204(5):777-92.

Lipidomic “deep profiling”: an enhanced workflow to reveal new molecular species of signaling lipids.

Narayanaswamy P, Shinde S, Sulc R, Kraut R, Staples G, Thiam CH, Grimm R, Sellergren B, Torta F, Wenk MR.

Anal Chem. 2014 Mar 18;86(6):3043-7.

TPS1 drug design for rice blast disease in magnaporthe oryzae.

Xue Y, Shui G, Wenk MR.

Springerplus. 2014 Jan 10;3:18.

Distribution of secretory phospholipase A2 XIIA in the brain and its role in lipid metabolism and cognition.

Ee SM, Lo YL, Shui G, Wenk MR, Shin EJ, Kim HC, Ong WY.

Mol Neurobiol. 2014 Aug;50(1):60-75.

A computational framework for integration of lipidomics data into metabolic pathways.

Hadadi N, Cher Soh K, Seijo M, Zisaki A, Guan X, Wenk MR, Hatzimanikatis V.

Metab Eng. 2014 May;23:1-8.

Targeting lipid esterases in mycobacteria grown under different physiological conditions using activity-based profiling with tetrahydrolipstatin (THL).

Ravindran MS, Rao SP, Cheng X, Shukla A, Cazenave-Gassiot A, Yao SQ, Wenk MR.

Mol Cell Proteomics. 2014 Feb;13(2):435-48.

LipidGO: database for lipid-related GO terms and applications.

Fan M, Low HS, Zhou H, Wenk MR, Wong L.

Bioinformatics. 2014 Apr 1;30(7):1043-4.

Critical role of SCD1 in autophagy regulation via lipogenesis and lipid rafts-coupled AKT-FOXO1 signaling pathway.

Tan SH, Shui G, Zhou J, Shi Y, Huang J, Xia D, Wenk MR, Shen HM.

Autophagy. 2014 Feb;10(2):226-42.

Lipidomic analysis of human tear fluid reveals structure-specific lipid alterations in dry eye syndrome.

Lam SM, Tong L, Reux B, Duan X, Petznick A, Yong SS, Khee CB, Lear MJ, Wenk MR, Shui G.

J Lipid Res. 2014 Feb;55(2):299-306.

Extensive characterization of human tear fluid collected using different techniques unravels the presence of novel lipid amphiphiles.

Lam SM, Tong L, Duan X, Petznick A, Wenk MR, Shui G.

J Lipid Res. 2014 Feb;55(2):289-98.